ID   A0A3P7PX85_DRAME        Unreviewed;       882 AA.
AC   A0A3P7PX85;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   ORFNames=DME_LOCUS5516 {ECO:0000313|EMBL:VDN55543.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|EMBL:VDN55543.1, ECO:0000313|Proteomes:UP000274756};
RN   [1] {ECO:0000313|EMBL:VDN55543.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   EMBL; UYYG01001152; VDN55543.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7PX85; -.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF73; INCREASED SODIUM TOLERANCE PROTEIN 2; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        290..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        452..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        495..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        539..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        676..699
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        727..751
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        830..855
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          17..279
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          282..869
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   882 AA;  103100 MW;  C8E7644B44B11C1F CRC64;
     MQSEQLETER KNERYSYFAD GRRRVDYVLA YHLIDNDFRD DLDDQRDSCE FSEDDDDIPH
     TYAFLGNLTR KAKRRRIYEE NLIRKGLELE HIKGKYCNNI GFVLVHIPFD LLCRHAEKMG
     IELRVRTDLR PKRNVEGSMF DKILNKCGLF HFDKRTNKLI EEPRNQYYPF NYDDMECFVG
     YNNPENFFSS ADRIFVVYDI LSHTKFGRDG RVGIELMLQK EIYNAAYPLH EFLDYDNLRS
     GLCKKEVVKG VDELSGNNTR QLLYWLWAKL RYCYKFQPLF LIKEYFGSKL AMYFVLVGYY
     TKFLIPCSII GLFCFMYGIF TFNTDIPSNE ICSANGELQE ILMCPICDRW CDYTKLNSSC
     FYSKLSYISD NISTVIFAIV MSIGATLFVE GWKRYNSDIA WRLGLLDTGS HEEGLRLAYL
     LQSLRVSNVR DPLTRRREPV PIPLSKRLPR AFASFITVIF FLCLILAAVI GTIIYRIVLL
     QVLYRVHSIR PFAMLFTSLT TATLNLVVIL IMSYFYSYLA LKLTDWEYPR TQSEFEKSYT
     VKVFLFQLIN WYSSIFYVAF FKGTFSGLPG RRIFGLRPEN CDPSGCMVEL VISLATIMLG
     KTLYNSAMEF FNPVFLTIFR GFTLKIPESR STRIEKFRRE KKKEMDSICI SVPRWEWDYA
     LTPIYEQFLF DEYLDIAIQF GFVTLFVSAF PLAPFFALIN NVLESRLDAY KFVVAMRRPI
     PERAKDIGIW LSIIDAIGKA AVITNAFVIA FTSDFIPRLV HIYRYSNLVG YISSKLSIFE
     PSSLHPAEWS QWHNVTKCWF IDYRKPPCSL SPRIGCDDAY GVTDLWWTVL AFRLGFVVVF
     AHVVFIIKAF ISYIIPDVPS RIFIQLQRQR SSSFDFMSTG TY
//