ID   A0A3P7SAL2_DRAME        Unreviewed;       290 AA.
AC   A0A3P7SAL2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=DME_LOCUS1355 {ECO:0000313|EMBL:VDN51382.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|EMBL:VDN51382.1, ECO:0000313|Proteomes:UP000274756};
RN   [1] {ECO:0000313|EMBL:VDN51382.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Dihydroflavonol-4-reductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00023445}.
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DR   EMBL; UYYG01000019; VDN51382.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7SAL2; -.
DR   STRING; 318479.A0A3P7SAL2; -.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10366:SF564; 3BETA_HSD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT   DOMAIN          1..121
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   290 AA;  32914 MW;  B94D50BC2C2A7CF1 CRC64;
     MVTGATGYIG IHCVQQLLKQ QYLVRGTVRN PDNEEKMKPL KSLEGSERLE LMKADLDHDD
     YWNEVVQGCD YILHVASPFV INDDDSIIKT AVDGTLRVLR AAQQSSSVKK IVQTSSIVAI
     NEKLFHKSNG RNFIDIHFKL TCINPVFVVG PALQEERGTS TMARVFWSAN QNFIYLPSKI
     SQLHSLIIFL NLQHLQIIKH FLDGRMPAYP AVQLALVDVR DVATAHIKAM CEPRTDGERI
     LIASQSSLWF REIAKILRDE FGSQGLLYLF HIDYRLQIFC ASNLSFSIYC
//