ID   A0A3P7SB03_HAEPC        Unreviewed;       580 AA.
AC   A0A3P7SB03;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   ORFNames=HPLM_LOCUS289 {ECO:0000313|EMBL:VDO04986.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|EMBL:VDO04986.1, ECO:0000313|Proteomes:UP000268014};
RN   [1] {ECO:0000313|EMBL:VDO04986.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO04986.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   EMBL; UZAF01000175; VDO04986.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7SB03; -.
DR   STRING; 6290.A0A3P7SB03; -.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0003990; F:acetylcholinesterase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000997; Cholinesterase.
DR   PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR   PANTHER; PTHR43918:SF9; CARBOXYLIC ESTER HYDROLASE; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR00878; CHOLNESTRASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT   DOMAIN          25..518
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   ACT_SITE        216
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT   ACT_SITE        344
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT   ACT_SITE        464
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
SQ   SEQUENCE   580 AA;  66553 MW;  FC8D461F69B79BB3 CRC64;
     MKCLLPLLLN PTLSFGRLFT KYFVEVETRL GKIRGQESIF LHRRVRSFLS VPFAEPPIGE
     QRFRPPKPKK PWNETITANT LSPACFQGRD MYNTSFWGSE MWNHNTPVSE DCLYLNIWTP
     ADAYNLTVMV WLFGGGYYSG SPSLILYDGK ALALLGNVIV VNVNYRVGPF GYLYMDHDEA
     PGNVGMLDQQ LALYWIRDNI FNFGGNPSRI TLFGESAGAA SIVAHLIAPG SENLFKNGIL
     QSGSLDNKWS MDSPTRALDK SLQLANLVGC NRTEMKDTIA CLRVTPAQVL IDNIWNLDLH
     FLEFPFVIVS RDKNFFRHKD GFISLRNGHY AHHVNLMFGI NHDEGNFWNI YNLGNYFDKA
     EQPELNRDEF HDCVERAFAF QPELVRSAAK HVYSDPNCTD PTKRTQFYAE QVNQMVGDYF
     FTCDSIWLAD QFRQNVERTG QVYIYYFDQP SSANPWPKWT GVMHGYEIEY VFGVPIYNET
     AKYTKREQIL SEKIIQYWSS FATTGVPRLR DAKSTDIWWM LLKGGSHVRP TPSRKKVECD
     LWRTAKDMEY NSYSTFQAEL LLSSAFRISL SSVLLVLVLS
//