ID   A0A3P7STH4_DRAME        Unreviewed;       314 AA.
AC   A0A3P7STH4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Peptidase M41 FtsH extracellular domain-containing protein {ECO:0000259|Pfam:PF06480};
GN   ORFNames=DME_LOCUS3802 {ECO:0000313|EMBL:VDN53829.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|EMBL:VDN53829.1, ECO:0000313|Proteomes:UP000274756};
RN   [1] {ECO:0000313|EMBL:VDN53829.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYG01000189; VDN53829.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7STH4; -.
DR   STRING; 318479.A0A3P7STH4; -.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.40.1690.20; -; 1.
DR   InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR   PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR   PANTHER; PTHR43655:SF2; SD01613P; 1.
DR   Pfam; PF06480; FtsH_ext; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        172..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          174..262
FT                   /note="Peptidase M41 FtsH extracellular"
FT                   /evidence="ECO:0000259|Pfam:PF06480"
FT   REGION          107..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  36901 MW;  984E75C18D6E19B6 CRC64;
     MNNATEAPHK QCFGSFMMIR INQKFFRTFY HINRTIGRYK CFYIPQFKGD TMFTNDDLTK
     LLNINMDRNM VFKISSLYNM PKGFEKFMRE KLKKTFEKIK KDMEEIEGEL ESDKNSKSEF
     ENLNQKKRKE ALESTKKRID QPTNPDSSGS SGSFDWQLTS FRDFKMSDKD KGFVFVATVG
     FLLALYLSNS YEEVSWKKFY SDFLEKGNVE RLEVVNNRWV RIIPTQYSTS GTIYYFNIGS
     VDSFERSITA AQHHLGIDIE NHVPVFYKNE FEFWHQLPNI IQFLIPVLIF GPFLYSVFKA
     RGVGGSGNDR IYRA
//