ID A0A3P7TD81_DRAME Unreviewed; 491 AA.
AC A0A3P7TD81;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 11.
DE RecName: Full=Lipase maturation factor {ECO:0000256|RuleBase:RU361229};
GN ORFNames=DME_LOCUS9772 {ECO:0000313|EMBL:VDN59799.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|EMBL:VDN59799.1, ECO:0000313|Proteomes:UP000274756};
RN [1] {ECO:0000313|EMBL:VDN59799.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maturation of specific proteins in the
CC endoplasmic reticulum. {ECO:0000256|RuleBase:RU361229}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361229}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU361229}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC {ECO:0000256|ARBA:ARBA00005512, ECO:0000256|RuleBase:RU361229}.
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DR EMBL; UYYG01001190; VDN59799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P7TD81; -.
DR STRING; 318479.A0A3P7TD81; -.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR InterPro; IPR009613; LMF.
DR PANTHER; PTHR14463; LIPASE MATURATION FACTOR; 1.
DR PANTHER; PTHR14463:SF5; LIPASE MATURATION FACTOR 2; 1.
DR Pfam; PF06762; LMF1; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU361229};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361229};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361229};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361229}.
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 82..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 227..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 316..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
SQ SEQUENCE 491 AA; 57530 MW; E071A4986E7B15C0 CRC64;
MLSMCPIFIL KNYREMDIGS IPLVISGSSR EVCQLKQEGL NILPIVINTL HLAPSYALQF
ILICGILLSS LTFIFDSFRN TISYFCLWII HLSAFQVGGV FLWFQWDTLL LESGAICILL
ANLPFIGATS ADNISLFLIR WLCFRLMFSS GLVKLLSHCP LWWNLAALDV HFESQCIPTW
IAYYAHQTQK WLRHLAVAIT FYILIILPPM FFLPLKTLRT YAFFPQILLM VLIMLTGNYN
FFNIICALLC LPILVSSNEY NFCKFFIFIN SFVPFASISK SAKSAIPSKI VHLHDSLNYL
QLTHAYGLFR RFYSRFLFEI FALFLYKHLV RLYLKSMTGA HGRPEVIIEG SYDAEGPWIP
FHFYAKPGRL DEMPRFIIPH QPRLDWQMWF AALGAYQQNP FFISLIYHLL RNNTDVTYLM
KKYPFERKLP TLIRAQLYFY HYTKPNHRGE WPKNYWMRNF QEEYMPPITM DHPGVLSYLQ
QNGFVLKVIF N
//
