ID   A0A3P7VV72_HAEPC        Unreviewed;       967 AA.
AC   A0A3P7VV72;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=R3H domain-containing protein {ECO:0000259|PROSITE:PS51061};
GN   ORFNames=HPLM_LOCUS10001 {ECO:0000313|EMBL:VDO38957.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|EMBL:VDO38957.1, ECO:0000313|Proteomes:UP000268014};
RN   [1] {ECO:0000313|EMBL:VDO38957.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO38957.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the NFX1 family.
CC       {ECO:0000256|ARBA:ARBA00007269}.
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DR   EMBL; UZAF01017192; VDO38957.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7VV72; -.
DR   STRING; 6290.A0A3P7VV72; -.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06008; NF-X1-zinc-finger; 5.
DR   InterPro; IPR034078; NFX1_fam.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR000967; Znf_NFX1.
DR   PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR   PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR   Pfam; PF01422; zf-NF-X1; 7.
DR   SMART; SM00438; ZnF_NFX; 9.
DR   PROSITE; PS51061; R3H; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          754..830
FT                   /note="R3H"
FT                   /evidence="ECO:0000259|PROSITE:PS51061"
FT   REGION          77..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          828..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          888..926
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          945..967
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        909..924
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   967 AA;  108232 MW;  5A74196582BBE6B7 CRC64;
     MPRSGGINAA HDIAFNPYAA PFIPSTAPPE FIDSTTQEPF ENTRGQTYRE NMSFAFDQRG
     SRPFRPMREY NRSRIPNAGV VPNTAQGYQA PNRNVSNKNR GGQVQGRRRT VRRMDSDDQS
     YQDKPMRGEI QYLLLHSDFD DQRGIWSCKT CYHMFHISNG CIINWAKKSR EDDNKWRCPT
     CQTKYGTIPY NYFCFCGKQR NPNPPIGEVP HSCGNICGGQ RAPGCPHRCN EPCHPGPCPE
     CPVMLTKRCN CGNVQKAIRC GSAVEVKCDK VCDRLLACGK HRCEQVCHEG NCGRCELKII
     QKQILISTLS ACFCGSSSRE VLCYEKGDSD SYSCGAPCSG MYTCGVHQCT RSCHLMGDSG
     CGPCPSAPER ITHCPCGRCT LEELGIERKS CHDPIPTCKN VCAKVLKCGA ADKKHRCRAL
     CHQGECPPCD LNTSVVCRCK QVKRTLPCVE YVHFAGEFLC EKRCKKRKSC GIHKCQELCC
     VQKEHLCLQI CNKRLSCGLH FCESICHAGQ CPRCLNSSFE EQYCHCGRTM RPPPVPCGAP
     LPECDEPCAR PHACNHPVTH HCHGDERCPP CTALVERMCY GKHELRKNIP CHIEAVSCGR
     LCDKPLGCGV HNCNRNCHAG DCMREGEKCT RPCMILRRPC EHPCSLPCHG LDPCPESECR
     HPVNVTCECG KRRSTLKCVE VRFAKRKESE GDPSNESAGV GSLKRSASME KLNCLPCDDE
     CKKSARNKKL AEALKLVTDE NGMLEREPTI TFTEYMKVEL RTNAAFVTES SAQLFSCFQP
     TFLGSSLNHN FRPMSVDKRR FIHEYAVFFS IETAGVDDPP KRSVIATAKS SFNDDPKRKS
     EQAAEEASTT SSMKALRGGR LFKKRVAPEL ARPAPLPQFN HFAVLRSDDE DTEPQAPSRK
     ADNVKNPDWW SDEEEEEEID SSDGADQEII ALMKDIVLQV CETERRDEQQ EHDLLSAGCK
     DSWSDEE
//