ID A0A3P7WL52_HAEPC Unreviewed; 362 AA.
AC A0A3P7WL52;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=E2F/DP family winged-helix DNA-binding domain-containing protein {ECO:0000259|SMART:SM01372};
GN ORFNames=HPLM_LOCUS13034 {ECO:0000313|EMBL:VDO47617.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|EMBL:VDO47617.1, ECO:0000313|Proteomes:UP000268014};
RN [1] {ECO:0000313|EMBL:VDO47617.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO47617.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; UZAF01018060; VDO47617.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P7WL52; -.
DR STRING; 6290.A0A3P7WL52; -.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF7; TRANSCRIPTION FACTOR EFL-3; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..362
FT /note="E2F/DP family winged-helix DNA-binding domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018026686"
FT DOMAIN 49..118
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 196..283
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
SQ SEQUENCE 362 AA; 41066 MW; 3574EC46A9F59DBE CRC64;
MISSAGSMQI LSLFLLCLES TLDSPRPFTM TTSSRRESSD DLEVEMTSRK EKSLGLLCQR
FLIAMNEETR MSSSREVHLE TVARKMNVEK RRIYDIVNVM EALDAMSKTN KSYYRWHGLE
GLPKLMADLQ KEAIDEHLPE RVLRVEQAMC SFTELSPGSR KIGAKEIVGE FVKIAFTYGT
GTGGEKRTRV EGRDRQGRNS LAQLCRRFLM VLLSNPKNTR RVSLDVASTV LIKDPDTEGF
EPPSRSRCRR LYDIANVLVA LGLIKKVHYL FGTKKIPLFV YCGPEPDENS TFDVNALAVA
FLVAEKSSYE TFEKLKSCIL KLNSCTSSPL FPEIRNMRVR NLPNFPGKNG SNFLSYLRWI
CV
//
