ID A0A3P7XXJ5_HAEPC Unreviewed; 2462 AA.
AC A0A3P7XXJ5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=HPLM_LOCUS8233 {ECO:0000313|EMBL:VDO34248.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|EMBL:VDO34248.1, ECO:0000313|Proteomes:UP000268014};
RN [1] {ECO:0000313|EMBL:VDO34248.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO34248.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAF01016814; VDO34248.1; -; Genomic_DNA.
DR STRING; 6290.A0A3P7XXJ5; -.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 10.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 8.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00060; FN3; 10.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50853; FN3; 10.
DR PROSITE; PS50835; IG_LIKE; 7.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 213..294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 298..395
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 387..481
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 484..582
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 586..682
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 689..783
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 796..885
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 876..972
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 977..1082
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1086..1165
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1170..1263
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1267..1372
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1379..1455
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1464..1575
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1580..1683
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1687..1781
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1884..1977
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 2372..2462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2462
FT /evidence="ECO:0000313|EMBL:VDO34248.1"
SQ SEQUENCE 2462 AA; 270184 MW; DB9C3ED568408765 CRC64;
MSSPPIPPPD AGKCVISKAS GREICYPRYE DLDTTCTDVT GRSSSGLVAP PVIPHATVRA
MAFVPPDNLR RLIVQYYRQQ GKLMPKNVTF SPKSFLFVKY HCDFGYEMVD EIDTLFCHQK
SWVNTLPMCR GKGQCAVNNG GCSHSCLSIN DVTVECRCPR GMTLDSDQKT CIKPIPKTLC
RSLAGCSCTA IDPNQYSCTC PKGAKCLLLK GAPKLYVEPP GPYEVPPGGN INITCSAVAY
PFPDIFWQRW VMMKDPGTVK NEQILIIKEL FKNAEFTCHA NNSEGKVDRT IKIIITGPGS
APVLRGALSG RTNIQVRWDP PHVINRPITS YTVYYTNNGN QPIKNWQRME VKEPNHSATI
ENLRPNTPYF IRLRANDQMG PGRLGNPASV TTLKPAARPL VFIEQGEELL VGPLKPFELG
CNITRADPVP IVTWQHKGRP LNNGERTMFM KMHIGGIIEN TVFACVAENE AGKSTKRINI
TVTGPTAPER IRYQVDGDKV NLQWEQPRII NAPMAGYDIL YTDNPNLPED QWQIERIDDP
LAHTATITGL KERTPYTFRI RGRNKLGEGL PSGPFNATTW LGARPPHVTV TPRGKIVKEP
SNEPLTIECE AIGVPKPKII WLWSGQLVED GKDEFRVYDI TPMDAQDRST SKLIAQSTTR
TGVATCQAVN AEGSDEKRTE VKILGPGSAP LNIQPTPMHT GFDVAWQPPK RPNGRIKNYI
VYYTKDPDQP LSEWKSETVG GDIRNLTVRV DDEDTPYVVK VQAATDDGPG IISEAYEVTT
GRKQIPLTVR LEISDPHVSE SDTETEVEPA QPIHFRCVAE GRPMPSVSYS WLPMNSTESG
DEPVPIPIQP DPAQEHRYYS IQVYSTTSTK RTLLCQARNP DGTVEDKHFF IVNKPGSPPR
DVNSYNVYLT GDPSQPVDQW QRFEVTDPNN PKLIFERGEL EPESPYYVRI AAVNPFGEGV
HSDASHFTTV SGAPIDSPSD ILPTVSDDNT VNISWFGPKE PNGPIKSYTI YFAPDDGTAE
DDDYKNWPRI EVPTSDDHGN VIIDKDQYDI KPNTPYKVRI SATNDQSEGP ASEPIHFETG
SGEMPPTITL DPPKNIVSVE PEGSVNIICT ATGLPQPIVY WVLENGEKIE GRALQLTNLI
KDTTATCRAE NRAGMTQEVV QVQVSGPGTP PNEIVLLPMP NQVINVEWTT PDEVNGRITN
YIVHYGEVPE GSEWKQATVD AIDVNHQLPN LDPKKNYAVR VQAVSDRGPG VISAPQMIRT
LPLAPAKIVN PEVTVFNNNS IVIDFVPPAD PDSPNKQIKD FVIQYTSEDP PTDETEWKEL
RFTDPDVTDN YTVVPIDGEN FNPDTKYHMR IIPRGEIDGP SSDLTTFTTG DGVITPSQPE
FNVDAPDNVI RVPAGTDYVV TCTSTGFPPP EIRWVDSEGN QLSDGPQLKL IDVRRTVKAK
CLAENRGGLK ETDFTVFVAG PGSAPENVQL HADKPVTISV QWDPPLIPNG NITKYIIYYT
PLDDQDPAHQ IGQVQSRPIN EWVTYHDTPD TNGTRKAELK DFVETDTAYA VVVQAINDDG
PGPYSNQYTI RTMSRAREGP PIDLRVDPDG QRSAIIEWKE PVTTDVKPLG YEIYYVPGDK
SVDADDLVLS DWWVIVIDDP SKLSHKIQNL LQPDTDYVFK IRAIYPDGPS VFSEPCIMKT
LPDGNAPYIQ ISTGENGVEG SSNIDVLPGS QITVSCNATG LPLPSVKWIR GGTYEIDPST
VDTAVSHAQF SLQVANITED TTFNCVAQNP LGHANWTINV NLLPGLEPEW KDDFVVSKTE
NGEVVLAFSD NLPDYLKPPS DWVIRYTDDP DLPKDEWKTI PSDSGPLTRI AVPDMEPGTY
YYLVVDSPDK GIQTPTLLVM TPKPPSEIRV GTNINDEAVV DFKDAITSQP IRKYSIKVWK
VDDPSNIKHY ETSPDVSSGV VLDGLERDTE YAVQVAAEFY EGDSLASEPV TVRIPPGGVA
CDCAHACTFE EQEDGTVTSK CYCHSGFVLG SDQKSCEPSS DAPTAYTIVR VTPPAFTTEV
QPEEISSTGI SASPLPTGVD GKTLEVEEIR STIRPTDSSG RELPLVVGPD GVPLSVNADG
ELVDNNKSPI IIEDGEPRDP FGNALPRNKD GAWIYPLIDK SGKPLPVDEN NMPKISVVMG
DGTEVQMDED GNFVGADGRV IPTDVIGRPL DEHGEPYEIN EEGQFVIESI ETEPVIEGED
MPSVPLLTVD GEPLTLDDSG HFVDSTGAII PTNEEGIPVD ENGNPLPKNK YGEYVLTTRK
EMGTISYPTD ESGNIMYPIK KPDGSLLPTD STGNYITEDG VVVERNEEGR PVGPDGEVLP
TDDAGNYIYP AFGPDGIPLP TDEHKRPIHP VFGPDGSPLP TDDSGHPLAK DGRPIPTDRS
GVPLGKGGKP LPTDSSGHYV TVPREEAASK EMPTDESGNV IYPVTKPDGS PLPTDASGNF
VT
//
