ID A0A3P8N7C6_ASTCA Unreviewed; 658 AA.
AC A0A3P8N7C6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=All-trans-retinol 13,14-reductase {ECO:0000256|ARBA:ARBA00041141};
DE EC=1.3.99.23 {ECO:0000256|ARBA:ARBA00038979};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000000666.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000000666.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000000666.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol;
CC Xref=Rhea:RHEA:19193, ChEBI:CHEBI:13193, ChEBI:CHEBI:17336,
CC ChEBI:CHEBI:17499, ChEBI:CHEBI:52075; EC=1.3.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00036004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR AlphaFoldDB; A0A3P8N7C6; -.
DR STRING; 8154.ENSACLP00000000666; -.
DR Ensembl; ENSACLT00000000681.1; ENSACLP00000000666.1; ENSACLG00000000495.1.
DR GeneTree; ENSGT00390000017613; -.
DR OMA; AFMFADW; -.
DR Proteomes; UP000265100; Chromosome 4.
DR Bgee; ENSACLG00000000495; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR46091:SF1; ALL-TRANS-RETINOL 13,14-REDUCTASE; 1.
DR PANTHER; PTHR46091; BLR7054 PROTEIN; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 658 AA; 72946 MW; E33CD87E2DA982A1 CRC64;
MEPNEEVNAV TVPSGLGRGA IMIAVSIICA AIVIFLLHYV FGGRGPDPFE KDTREPLKKR
VYDKKEKNKV LKQGFVANRV PENLDAIVIG SGVGGLGLAV LLAKVGKRVL VLEQHSRAGG
CCHTFTEKGF EFDVGIHYIG ELLDHKPFRC MLDQMTNGQL EWEPLENPFD HVVLGPPENR
RRYPIYSGRT RFTDELKKCF PGEEKAIDEF MKLAKKTGNG VWFLALLKIL PLPLAKFLVH
TGLLRHLSFF FKMAPRSLTD VVNELTENKD LRAVFSYIFG TYGKIPKEAS FAMHSLLVTH
YLNGAWYPKG GASEIAYHMI PIIEKAGGAV LVRAPVNRIL FNDAKEACGG SSVSLHTVSS
TSHRGGDSLC LCFMVSGVSV MKGQEEVHIH APLIISDAGI FNTYQKLIPK DLQTMPAIQK
QLSMLKHGEG GLSVFMGLNG TKEELGLKAD NYWIFAENNF DELVMNYMKK DREEAAKNVP
LLFVASPSAK DPTWEARSPG KSTLSLVTFA KYEWFEEWKD GKVTNRGRDY TELKQAFIDT
ILEVVMDVFP KITRDKIEYI DAGTPITNTH YIGAPKGEIY GADHGISRFD PELNITVRAQ
TPLKNLYLTG QDVFLCGFAG ALAGALTCGS AILKRNLHLD TIALAKRTAF INTKLKGE
//
