ID A0A3P8N7J2_ASTCA Unreviewed; 147 AA.
AC A0A3P8N7J2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Glycoprotein hormone subunit beta domain-containing protein {ECO:0000259|Pfam:PF00007};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000000722.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000000722.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000000722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC {ECO:0000256|ARBA:ARBA00003920}.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC {ECO:0000256|ARBA:ARBA00011870}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU004069}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552, ECO:0000256|RuleBase:RU004069}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8N7J2; -.
DR STRING; 8154.ENSACLP00000000722; -.
DR Ensembl; ENSACLT00000000741.1; ENSACLP00000000722.1; ENSACLG00000000525.1.
DR GeneTree; ENSGT00940000161285; -.
DR Proteomes; UP000265100; Chromosome 12.
DR Bgee; ENSACLG00000000525; Expressed in spleen and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF11; LUTROPIN SUBUNIT BETA; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU004069};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 69..139
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
SQ SEQUENCE 147 AA; 17203 MW; 9A089DEBF7D6FCE8 CRC64;
MSLHLFYHYE PPIKLFHKNC ISYLFSHVPW WRLTLSRGQV LSAFTSQSVC FYFQSFIHSF
IHSLLIVETI DPVIKIPFSN VYQHVCTYRD LYYKTFELPA CPPGVDPIVT YPVALSCHCG
RCAMDTSDCT FESLQPDFCM NDIPFYY
//
