ID A0A3P8N7R4_ASTCA Unreviewed; 956 AA.
AC A0A3P8N7R4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=MAM domain containing glycosylphosphatidylinositol anchor 2 {ECO:0000313|Ensembl:ENSACLP00000000795.1};
GN Name=MDGA2 {ECO:0000313|Ensembl:ENSACLP00000000795.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000000795.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000000795.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000000795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8N7R4; -.
DR STRING; 8154.ENSACLP00000000795; -.
DR Ensembl; ENSACLT00000000815.1; ENSACLP00000000795.1; ENSACLG00000000588.1.
DR GeneTree; ENSGT00940000155369; -.
DR OMA; AYSLEWT; -.
DR Proteomes; UP000265100; Chromosome 15.
DR Bgee; ENSACLG00000000588; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF33; MUSCLE ASSOCIATED RECEPTOR TYROSINE KINASE; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 4.
DR Pfam; PF00629; MAM; 1.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 6.
DR PROSITE; PS50060; MAM_2; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..956
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017925317"
FT DOMAIN 27..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 134..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 243..328
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 341..437
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 443..534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 541..629
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 748..924
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
SQ SEQUENCE 956 AA; 107116 MW; 4EBBD44D330694EA CRC64;
MDLTICVLGL LALIVDGIRC QGVYAPPTVR IIHSGHACNV EEERHTERVY TIREGETLEL
TCLVTGHPRP QIRWTKTAGS VSDRFQDSSV FNETLHIAKI QRTQGGRYYC KAENGLGSPA
IKSIRVDVYY LDDPVVTVHQ SIGEAKEQFY YERTVFLRCV ANSNPPVRYS WHRGREVLTQ
GSDKGVEIYE PFFTQQGETK ILKLKNLRPQ DYANYSCIAS VRNVCGIPDR SVIFRLTNKT
ASPSIKLLVE DPIVVNPGQT VSLVCITTGG EPPPILTWVS SNDSLPQRSV VKGGTLTLPA
ITSDEAGVYS CVASNNVGNP AKKSTTIVVR ALKKGRFWIT PDPYHNDDHI QIGREVKISC
QVEATPPEEL TFSWLKNGRA LRSSERMVIT QTDPDISPGT TNLDIIDLKF TDFGTYTCVA
ALKGGGIPEI SIDVNISSTT VPPNLTVPRG KSPLVAREGD TVELECLVSG KPKPIILWSR
ADKEAPMPDG SMQMESYDGV LRIVNVSREM TGSYRCQTSQ YNGFNVKPRE AIVELIVQYP
PTVEPVFMEM RQGLGRPVVM TCRVLRAHPS RVLRFEWLLS NRLLHAGAFD TQRDETEYTI
RSLNRDGWGE YTCNVINEAG AGKCTFQVTG KAYPPEFYYD TYNPLWQNRP RVYGFKLQWT
QMNPNAVDRI VAYRLGIRQM GLQRWWEQEI PVDGTINKGE LMTHNLTELI KPESYEVRLT
PITRFGEGDS AIRIVTYSAP INPHLREFHC SFEEEPICMF TQDKNDDFDW TRHSAATRDT
KYTPNTGPSG DHSGSKQGFY MYIETSRPRK EGDQARLISP FFNVAPKNPY GITNPPAYCF
GFFYHMYGKH IGTLNAFLKQ KGQTASEGLV WSLSGNQGDR WKQAKVSIHP TSSFQVVLQG
IRGPGIEGDI AIDDITLEEG ECRDPPPNLS AKALSTSCHI WLLCVTLVLT LLEGQR
//
