ID A0A3P8N8U2_ASTCA Unreviewed; 917 AA.
AC A0A3P8N8U2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Glutamate ionotropic receptor AMPA type subunit 1 {ECO:0000313|Ensembl:ENSACLP00000001164.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001164.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000001164.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000001164.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8N8U2; -.
DR Ensembl; ENSACLT00000001193.1; ENSACLP00000001164.1; ENSACLG00000000782.1.
DR GeneTree; ENSGT00940000157342; -.
DR Proteomes; UP000265100; Chromosome 2.
DR Bgee; ENSACLG00000000782; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0022824; F:transmitter-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd13729; PBP2_iGluR_AMPA_GluR1; 1.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF157; GLUTAMATE RECEPTOR 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..917
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018260500"
FT TRANSMEM 534..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 407..807
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 417..482
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 570..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 102110 MW; 0A2483224A015A73 CRC64;
MQRSFTILYT SLLGMCLGSS SSFPSNINIG GLFPSGSHEY EVFRFALSHH QDIPKLVPQV
DMVMMGNSFS MTYAFCSQFS KGVYAIIGLY DRKTVNMLMS FCGALHVCFV TPSFPIETAN
QFVIQLRPEL QDALVGVIEH YGWSKFVYMY SSNSGLSVLQ KVLDTAAERN WLVTSVNVET
ISSNAFAKVF QDLDKRKEGQ IIIDCETERL NNILQMIVDQ GKNAKSYHYI LANLGFLDID
LTDLRKGGAN ITGFQLVNNS EPSVSRIVQQ WMEFDNKDSK VPKPGLKYTG ALTYDGVKVM
STAFQNLRRQ RIDISRRGNA GECLANPPAP WGQGIDIQRA LQQVRIDGLT GHIQFNEKGR
RTNYTVSVME LAPSGPKKVG YWNEDEKYVT TASLRGSNET YPLLNRTYIV TTILESPYVM
LKKNHEQLVG NDKYEGYIVE LAAEIAKHVG YQYKLKIVSD GKYGARDPET KMWNGMVGEL
VYGKADVAVA PLTITLVREE VIDFSKPFMS LGISIMIKKP TKSKPGVFSF LDPLAYEIWM
CIVFAYIGVS VVLFLVSRFS PYEWHAEDYE EGAEPQTPTQ AAASNGVQQG QTPTQQNTTQ
QSPEQTNEFG IFNSLWFSLG AFMQQGCDIS PRSLSGRIVG GVWWFFTLII ISSYTANLAA
FLTVERMVSP IESAEDLAKQ TEIAYGTLDA GSTKEFFRRS KIAVFEKMWS YMKAADPSVF
VKTTDEGVMR VRKSKGKYAY LLESTMNEYI EQRKPCDTMK VGGNLDSKGY GIATPKGSHL
RIPVNLAVLK LNEQAVLDKL KNKWWYDKGE CGSKDSGRKT SALSLSNVAG VFYILIGGLG
LAMLVALVEF CYKSRTESRR MKQSINDAMH CSTLTRMSGN GSGGENGRIL THDFPKTVQT
LPCMSHTASM GLGASGM
//
