ID A0A3P8N9Q2_ASTCA Unreviewed; 2080 AA.
AC A0A3P8N9Q2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Latent transforming growth factor beta binding protein 2 {ECO:0000313|Ensembl:ENSACLP00000001439.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001439.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000001439.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000001439.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8154.ENSACLP00000001439; -.
DR Ensembl; ENSACLT00000001472.1; ENSACLP00000001439.1; ENSACLG00000001019.1.
DR GeneTree; ENSGT00940000155823; -.
DR OMA; ADPPHCA; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000265100; Chromosome 19.
DR Bgee; ENSACLG00000001019; Expressed in spleen and 6 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 18.
DR Gene3D; 2.10.25.10; Laminin; 24.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 22.
DR Pfam; PF00683; TB; 4.
DR PIRSF; PIRSF036312; Fibrillin; 12.
DR SMART; SM00181; EGF; 25.
DR SMART; SM00179; EGF_CA; 23.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 7.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 12.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2080
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017992636"
FT DOMAIN 180..212
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 415..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 568..610
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 638..678
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 688..740
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 927..963
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 970..1009
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1050..1089
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1090..1130
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1383..1422
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1423..1464
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1465..1505
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1549..1591
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1655..1709
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1778..1818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1836..1889
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2023..2067
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 49..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..803
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 184..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 202..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 419..429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 437..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2080 AA; 226704 MW; C1F45643CDD70C8D CRC64;
MPKMDRAGFA LLMILTVVLV RVGDGQRDAA GGRKEGAGAG RAVWDQLQSR GISRGHSPRG
PRDGSSSRTS SDSSPGTSQS RTLVRLPRGT SSQENRKHIS KERPVHAAAT SGEDLVSAPR
DGARRTARHP TSQQQRNRVN RRQSSRHSSA STKRLIGPNV CGGQQCCSGW ALAPGTNRCI
KPDCQPPCQN RGSCSRPHTC VCRSGFQGAR CEEVAPEQVY IRDRGALRRV QPGTNPFQKD
QSQKRPSERD TIDTTKAKTT RPSTTRQPAH TATQVRRGPP DSSPQQTGTS RTVKRYPSSS
GPITSNALPN GNGYSNGNEH GNWYGNRNGH TNTHSHNTHR PTSNSQLHGQ FSNALLPAGA
NLTSNLDRIK IVFTPMMCRR VCSGGRCYNS CEKGDMTEVY SETSPHQQPK NQGFRLFFCQ
IPCLNGGRCI GRDMCWCPSN STGRFCHLPV PPPARPTPQS HRNHQKPKSP SHSMYTLPLS
NQPVSLHPSL VNVHIQHPPE ADVQIHQVAR VQPGQRPATT EGAHSVQQRS QPGNGHEHAS
EHSSRHPHAN GNGHGHATTH IRQNGNVGRC FQETVDGQCG KPLPGLTKQD DCCGSIGASW
GLNKCQKCPT KPAYAVIANG QVECSKGFKR MNVTHCQDIN ECLLPGICKN AECLNTKGSY
RCTCKPGYML DPARSHCVSD KAVSDQRAPC YRSVSAATCS LPLTNHLTKQ ICCCSRVGKA
WGAGCDRCPL PGSDHFKEIC PAGHGYTYSR SDVQISLRQL DDVELQSMGV SLEDESPTYP
QFPFSQPSFP SGPQYPSYPE TPQLPQYPEY SETPQAPQYP LTPQHPSHPA RETPRPPHTD
DVESLSPPAV GTELPPQYPD IFPDFPSINP RPDSKEPSHT DSATGIDKCA TTPSICGRGR
CVSVQTGYIC LCEPGFKLSA LQTNCIDVNE CDEDPCEGKG RCINSYGSYT CHCHSGYSQV
ITQNRKFCQD MNECSMPNKC QNGKCVNTEG SYTCECNAGY AKSRRGVCED IDECRDPSSC
PNGVCVNTLG SFRCQVCGPG FRPVGERCVD MNECLNQSVC GRGRCVNTEG SYRCNCFQGY
KLSPDNVCQD VDECLLPGVC LNGRCVNLDG TYRCTCNHGY QVTSDSKSCE DVNECATGNA
CPAGICINSA GSYTCQNCRP GFEPSADRLR CEDVDECSQG DLCLGGVCAN TEGSYICTRC
KAGYRVSQDQ QRCEDIDECQ SLSTCVNGIC LNSEGSYTCE NCPTGYRVSF DGELCEDIDE
CALPTACPQG TCTNREGSFT CVVCEPGFRV SEDGQRCDDV DECSVANLCP GQLCLNTEGS
YTCRSCEAGF QVNEGGRYCE DIDECQSPSA CPTGVCANTE GSFSCMACDP GFELAFDRRS
CEDVNECEDA RLCVGGQCTN AIGSYSCSCP SGMELVDGTF CRDINECLTA GGICGEGDCL
NTEGSYLCIC PNGYTTTDGS PGCQDVDECS KDDVCIRGKC INGEGSFLCL CEAGFKFNTD
TADCEDQNEC KEFGSSVCGT WRCENTIGSY RCFVGCQPGL EGELATGCDI DECDNETICG
SNGFCENTDG SFRCQCDRGY TNPPGDMTRC VDVNECEMSL ALCGEALCEN FDGSFLCICP
NDNEEFDPRT SQCRSMAERD TKPIPAFPTS AEERRECYYN LNDANFCDNV LSHNTTKQEC
CCTAGAGWGD NCEIHACPVQ GSDDYKQLCP YGSGLLPLPV SSVQSFGDEQ RAYIDANECE
IFGPDICKNG QCSNLFSTYT CYCRSGFFYD NIRLECVDYD ECAFGNVCEN GVCVNTAGSF
NCFCSPPLVL DSTRRRCIDL NTTEEVVDSE DDVHVDICWQ QLEGDNMCAK PLSDRRTTYT
ECCCLHGVAW SEHCALCPRK DSADYAVMCN VRGSSDSLRE RIGYEYGVEG IDDPAEHFGP
PYWDHYGGAG GPYDISEGEN YYGIQQPPLH VPVRVPSVQP REYQPQRVDP YAERYEGFEG
LRAEECGILN GCENGRCVRV REGYTCDCLD GYELDLDKMA CIDINECEDI SDKVPLCQNG
ECTNTEGSYK CTCLPGFVAS AKPHKCIPAI PESRLREAGN
//
