ID   A0A3P8N9S5_ASTCA        Unreviewed;       250 AA.
AC   A0A3P8N9S5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Dickkopf WNT signaling pathway inhibitor 3 {ECO:0000313|Ensembl:ENSACLP00000001459.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001459.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000001459.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000001459.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
CC       {ECO:0000256|ARBA:ARBA00010842}.
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DR   AlphaFoldDB; A0A3P8N9S5; -.
DR   Ensembl; ENSACLT00000001492.1; ENSACLP00000001459.1; ENSACLG00000000990.1.
DR   GeneTree; ENSGT00390000000221; -.
DR   Proteomes; UP000265100; Chromosome 1.
DR   Bgee; ENSACLG00000000990; Expressed in camera-type eye and 7 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR   CDD; cd23274; Dkk3_Cys2; 1.
DR   Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK1-4.
DR   InterPro; IPR047300; Dkk3_Cys2.
DR   PANTHER; PTHR12113:SF8; DICKKOPF-RELATED PROTEIN 3; 1.
DR   PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..250
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018264919"
FT   DOMAIN          92..141
FT                   /note="Dickkopf N-terminal cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF04706"
SQ   SEQUENCE   250 AA;  27662 MW;  98659E2FB5C0C4C2 CRC64;
     LFLLLFHLLR AVCNGILPEI VDPGISHILE NDSAQGQAEP DSVFVEVEQL PEDQQQKPED
     SFHQVSSQLH LSLSFLHDIY SNDLENRVDH GCISDDDCGK GRYCLHDPHN AKCLPCKALD
     MSCTKDAECC GEQLCVWGQC SQNATKGEAG STCQYQTDCS PDLCCAFHNV LLFPVCSAKP
     IERERCFGAS NHLTELLSWG PQDEGPRKYC PCAGDLHCQD LGRGSMCLKG EDSSEEDLAD
     TLYSEIDYIL
//