ID A0A3P8NAI2_ASTCA Unreviewed; 1221 AA.
AC A0A3P8NAI2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neuronal cell adhesion molecule-like {ECO:0000313|Ensembl:ENSACLP00000001807.1};
GN Name=NRCAM {ECO:0000313|Ensembl:ENSACLP00000001807.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001807.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000001807.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000001807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR Ensembl; ENSACLT00000001602.1; ENSACLP00000001568.1; ENSACLG00000000954.1.
DR Ensembl; ENSACLT00000001846.1; ENSACLP00000001807.1; ENSACLG00000000954.1.
DR GeneTree; ENSGT00940000155419; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000000954; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 4.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1221
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040591807"
FT TRANSMEM 1159..1180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 130..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 253..341
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 346..434
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 440..527
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 531..618
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 634..729
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 731..828
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 833..934
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 938..1034
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 1221 AA; 136942 MW; 83137D4D395A02A1 CRC64;
MEWRRMDVGV LLLFLVHLAT ALEVPLDLPQ PPTITYQSPK DYIVDPRENI IIHCEAKGKP
HPSFSWTRNG THFDVENDPN VDMKPQSGTL VVDISRERVE HYEGVYQCTA RNKHGTAVSH
NIVVRQSRSP LWSKEKIKPI VVQEGVSLVL PCRPPAGLPP PIIFWMDNNF QKLPQSKRVS
QSLNGDLYFS NVRREDTRND YICYARFPHT QTIQQKQPIT VRVLNLDEIN DTMAAFYNDT
DLFSEAPVDD RRPTFLIPSG SSSSKMVLRG DKLEMECIAE GLPTPHISWT KISGDLPSKR
TSFLNYNKTL HIEDVSASDE GDYRCTAKNQ FGSVHHTIHV MVKAAPYWID VPPRNLVLAP
GESGRLSCLA SGTPKPTITW AMNGISIENS PKDLSRKVED DIIIFTDVQP GSSAVYQCNI
SNEYGYVLSN AFVNVLSEPP RVLTPPNKVY QIIKNHQALL DCSSFGSPMP KITWFKDSRS
SILQEDPYIL HDNGTLEIRV AQAQHNGKYT CVATNSLGIY ENHVYLEVKE PTRILKQPEY
KEVQRGRSVV FECTVKHDPS LIPTMTWLKD DGELPDDERL IVDSDSLTIT DVTEDDAGVY
TCIMNTTLDH DSATAKLTVV EATTPAVVYE RPDPPTDLEL TDQKKRSVQL TWTPGDEHNS
PVQKFLIQYE DSLHHRGHWH NLTEVPGTKT TAHLKLSPHV HYTFRVLALN AVGFSNPSRP
SRMYKTEPAA PDENPTGVQG FGTEHNNLVI SWKPLTNLQS NGPGLHYRVM WRQKKVESEW
NTVTVSNNSK FVVSGTPTFV PYEIKVRAVN DHGAGPDPAI AHGYSGEDLP VAAPENVHAV
VRNSTLVEVF WDPVPAHLIR GNIKGYKVSY WRKHHYKHNP DHMEQDILVF SGNHTQGMLP
GLHPFSLYLF NVRVYNGKGE GPRSVTQQFK TPEGVPGSPT SLIVTNSNLD SLTLEWSPPH
DHNGHITGYT LKYQPVNNSN ELGPVEELAL AANETSVTLP NLKYSIRYKF YLNAKTGAGA
GAAISQEAVI IREEGSTQSL HPIARSPPHG PPHKASPFGN ISSMIGEDWA LISWEYWGPE
KNFSAQYRLN DSESEEDWNT EFVNGSQNIT LKGLKGGLCY RVRLVALGHH DQEFHHSKEL
LVTLPAVASR QVDIATQGWF IGLMCAIALL ILILLIICFI QRNKGGKYPV KEKEDAHTDP
EFQPMKDDDC TFVEYRVTSS S
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