ID A0A3P8NAP8_ASTCA Unreviewed; 4015 AA.
AC A0A3P8NAP8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSACLP00000001877.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001877.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000001877.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000001877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR STRING; 8154.ENSACLP00000001877; -.
DR Ensembl; ENSACLT00000001918.1; ENSACLP00000001877.1; ENSACLG00000000997.1.
DR GeneTree; ENSGT00940000163761; -.
DR OMA; NSGMRVQ; -.
DR Proteomes; UP000265100; Chromosome 12.
DR Bgee; ENSACLG00000000997; Expressed in muscle tissue and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071711; P:basement membrane organization; IEA:Ensembl.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0010669; P:epithelial structure maintenance; IEA:Ensembl.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR CDD; cd00064; FU; 13.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 4.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
DR PROSITE; PS01208; VWFC_1; 5.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3910..3931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..90
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 95..155
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 159..219
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 221..281
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 285..345
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 349..412
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 496..542
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 496..542
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 1100..1200
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1220..1310
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1331..1442
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1467..1563
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1599..1694
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1715..1816
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1839..1941
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1963..2063
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2084..2183
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2205..2297
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2317..2410
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2445..2542
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DISULFID 497..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 4015 AA; 443206 MW; 1C5416F0D63B363E CRC64;
MKELLRSPRF CCSGPVRIIS HFYVCFDPLL ACRPICRKNN TSWRPQSCQE CTCYGDVAIC
GPTHCPNPHC DLQRGEHLRI PTNKCCPECA SSSQGSCQYE GVIYGHDSQW SPSPCSVCTC
SGGSVSCSTR PCPHLTCPGD QSLFTPAGEC CPKCASNGES CSWQGIVYRD GEEWKPSLCS
RCVCSNGEVQ CSVAECQQVA CKPHENLVIQ PGECCPQCVS NPCLSAGKQY QHGEQWQKNT
CTTCVCDRGQ SKCHTKTCPP ITCDKGQTKV KRAGQCCDEC AAAKGSCQYQ GAVRYHGDMW
NSTGCEFCTC SRGQVLCQRA ECGRVECPQG SELVNLPGKC CPECSSAKPS CVHKGKSYKV
LLSQNLARWS DGSCRECECH DAQVTCYLRS CRTCPLGTLA VIQDGQCCPE CHQVQCHADC
LSCSGTSDHC DSCRDPQALL HLGRCLSVCP VGFYAEGRVC AACQSSCATC SSRWDCQSCG
SRLPLLNPDR SQCLASCPPG SYQHDPTHCR YCHESCSECR GPSQQECVSC SDPVALLKDG
VCVLDCGTGF YSREGVCHAC DSSCASCFPD NPKCMSCPPG TALHHGKCLS QCPAQHYLDS
QSRCRACHSS CASCWGPSVS QCTLCPGGLL LHQGQCVEAC GEGLYAQDYT CHNCHPSCRS
CVGPLASDCL RCLKPEEALL PQSSHLQHSV CTAGCPTRSF LDDMQTCREC HPSCWQCAGP
SADNCTSCPS PSSLYEGRCV PTCPQGFLIQ DNQCQACHPS CQTCSGPSQA DCIACPPLVS
LQSGHCRANC QEGHFLNAIS GECVKCSSDC QRCTADLQTG VGSICLWCKA PRTWLLGDHC
VSHCPLGHYG WHGACIKCHP SCEACSGAGP LSCTSCPANS VLLPSGLCAP KCPLGYYNNG
QRICQACDSQ CLTCETPGVC TSCRDPAKVL LFGECQYDSC AHQYYLNTTT RTCRECDWSC
NACKGPLRTD CLQCMEAYVL QEGVCTQGCS FGSYRDGDRC LGCDDHCLDC RGPGQCQECQ
PPYATLHGQC VLECGRNYFL DASSKACKSC SSDCVLCDGN GLCRACRNQT YLMEGYCTPD
CGHGYYADQK TRTCHVNAHT PALHVNGSLL VPFDGFAPLL PTLLQVKDPD SPSEQLIFQL
VQKPSNGRLV LFRGEEGEET GGREIKKDDT FTWAELRHGR VRFQYQRDKD RSGEFTLRVA
DPQLFSQPKT IQVRAVSMQP PRVVTFSPLI VEGRGSLATI TKSVLQVDDP DNAADVLVMV
LEPPRYGRLT RLHSDRALSR FKLEELSREQ IQYIHDGSEG AEDGAVLQVN DGHSYKNILL
RVQIHHKPGD SPHMLSIPVT WVKEGGMVRL DKKYLQTDFK GVSTDNIVYS ILPSEGQPKY
GEVLLVSMPA DGPPEGWLPS LTDDRSFTAT TSFTQQDVND GAVWYRHFGT GSSGDSFLFQ
VSTEAEPVVQ SDAQTFTIGV MPQIPGFPQL APDCDLQITA LEAQVTEITP SALSFVDSET
PSEKLVYSIT KPLPSGQGTI EHRDRPYTHV QHFTQADVNN GKIIYRPPQA PSHLQELYQY
SFTGLPESLS VYFTVSDGEH NTPELDFAVL LLTNHQQPPV FQVLDPLLEV SLRGQAAIGG
QQLAVSDVDT APDELEFEVV EAPVHGELIK TDGNTKIRMT NGDTFTFSDV TRNVLLYHHS
GLSTQDDAIT FSVSDGISMA ATVVQVVVLG AGGSGPQQDP IATLSLEVGE KSSTVIRRSH
LAYTDDSSPD DQIRLQLVSV PMYGILTRSQ SQQEHQELRE YSSFTMEDIN KHRIRYITSI
ETGSQPVTDI FHFVVYDGDN NRLDNQICTI TITSAPRQPP LVTVRSSIKV EEGGRVQLST
NDITVSDVDT PPKDLLIWLV SPPKYGFIEN TRTGSSVGGS HVVTPDVPFS VEDLTSGHIS
YVQESQLKPQ TKQDIFSVYI SDGLSQTEAF SVEIDIQQSK EDKEPVVSVS SIHIEENSGV
VITNSSLSVH DQDTPENEIL FTIIRIPSYG KLRRRQFYSQ PLENGRVLTQ GSTFTYQDVV
DQLLVYTPET VSGGADEMAF TLTDGIHTHT GRLEFTMDVT RSEGPRMTVN RGLQLPAGSS
SKITEQNLKG TDIDSDHLKL RYILTKDPPV GKLQLNRSSR AESVSVRGPI QSFTQEDVNK
GLLQYSHEKG EKGGSLSFKF NLLDPEGNKL IDQSFFISVL EDHLPPSVVV NKGLVLDENS
VKKLTTLQLS ASDQDSEPGE LIYRVTKQTS LGHLEHTASP GTRISTFTQA DLASRSIQYV
HSSEEEKHAD QFSFTVSDGT NEVAQTFYIT IKPVDDSLPL LQVPGMRVQE GVRKTITEFE
LKATDADTEA ESVIFSVVQA PRHGTIERTI NGQHYRQTSS FTMDDIYQNR ISYNHDGSNS
LKDRFTFTVT DSTNLLFMVE DDGKEIVTAA PQKFKIDILP VDDGTPLIFT NLGLQWLEYM
DNKATNLITK KELLTMDPDT DDGQLVYEIT TEPKHGFLES KLKPGNPITT FTQADINLGL
IRYVLHQENV QETMDNFKFL VKDSKPNVVS DNVFHIQWSL ISFEHKSYNV SEKAGTVAVT
VKRTGNLNQY AIVLCRTEQG SATSTSSVGS RPGQQDYVEY AGQVQFDERE DTKVCTIVIN
DDKVFEGIES FHVELSMPVY ALLGGNTRAV VNINDTEDEP TLQFDKKIYH VNESSGLIHA
PIERKGDTSS TVSALCYTVA KSAQGSSLHA LESGSDYKSR GMTTDNRVIF GPGVSMSTCD
VKLIDDSEYE LSEEFELVLS DTSDNARMGD VSVAKVIIDG PNDASTVSLG NATFTFSEDA
GTIEIPVLRH GSDLSSLTSV WCATRPSDPP SASPGVDYIP SSKKVEFKPG KTDETCSLTI
MDDIQNPSIE GSESFVVFLS SPQGAVLQEP YEANVIIADT FQDIPNMQFE KSSYTAKEKD
NLLHIPIIRT GDLSFKSSVR CFTRTMSAMV MDDFEERRNA DESRITFLKG EKVKNCTVHI
IDDSVFEPEE EFQVHLGTPL SDHWSGAMVG ANDIVTVTIT NEEDAPTIEF EQASFQVREP
PGPDGIEVLN IKVIRRGDLD RTSKIRCSTR DGSAQSGVDY NPKSRVLKFT PGMDHILFKV
EILSNEDREW HESFSLVLGP DDPVEAVLGE ITMATVTILD QEAAGSLILP ATPIVVSLAD
YDHVQEVIKE GSKKTPSPGY PLVCVTPCDP HYPKYSVMKE RCEEAGINQT QVHFSWEVAA
PTDTSGARSP FETVTDTTPY TSVNHMVLDS IYFSRRFHVR CVAQARDKAG HLGTPLRSNI
ATIGTEGSIC HTPVTTGTAR GFQAQSFIAT LKYLDVKHKE HPNRIHISVQ IPHQDGMLPL
VSTMPLHNLH FLLSESIYRQ QHVCSNLVTL KDLQGIAESG FLDDVSYDSI SLGPGYDRPY
QFNPNVREGK SLQFYKHLNL KSCIWTFDAY YDMTELIDVC GGSVTADFQV RDSAQSFLTV
QVPLYVSYIY VTAPRGWASL EHHTEMEFSF FYDTVLWRTG IQTDSVLSAR LQIIRIYIRE
DGRLVIEFKT HAKFRGQFVL EHHTLPGHKS RLMAPDHLGG IEFDIQLLWS AQTFDSPYQL
WRATSSYSRK DYSGEYTVFL VPCTVQPTQP WIDPGDKQLS CTAHAPEKFL VPIAFQQTNR
PVPVVYSLNT EFQLCNNEKV FMMDPATADV SMAEMDYKGA FSMGQTLYGR VLWNPEQNLN
AAYKLQLEKV YLCTGRDGYV PFFDPTGTLY NEGPQYGCIQ PNKHLKHRFL LLDRKQPDVC
DRFFHDVPFE AHFASDIPEL QSMTAMPGVD GFTMKVDALY KVEAGHQWYL QVIYVIGPES
RSNPRIQRSV TYQLSRSKRD LVDRSGRLTL DESLIYDNEG DQIKNGTNMK SLYLEAGPSP
TFNAHVGSSV GGGVAAITLL VLVLLASCFL FRRCRRLAKK KSKKKEPKIY EEYPLNTKVE
VCMDKCVEKN FGTKHCTVRN INVLNRNQEA NSKAKVKQVN LEVKLHNNLN DGTEV
//
