ID A0A3P8NAX0_ASTCA Unreviewed; 353 AA.
AC A0A3P8NAX0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Tumor susceptibility 101 {ECO:0000313|Ensembl:ENSACLP00000001839.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001839.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000001839.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000001839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR AlphaFoldDB; A0A3P8NAX0; -.
DR Ensembl; ENSACLT00000001880.1; ENSACLP00000001839.1; ENSACLG00000001235.1.
DR GeneTree; ENSGT00940000153903; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000001235; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF17; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..146
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 285..353
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT COILED 202..274
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 353 AA; 40499 MW; D7273D3CF6845D86 CRC64;
MAVVNESNLK KMLKQYKYRD LTVREITNVI SQYKDLKPVM DAYVFNDGST RDLMSLTGTV
PVSYRGNVYN IPVCLWLLDT YPYNPPICFV KPTSAMMIKT GKHIDANGKI YLPYLHEWKH
PQSDLYGLIQ VMIVVFGEEP PVFSRPTTQA PYQAFQAAGP PNFVVVSFFP SGSPVHCPNR
DGTIGEDTIR ASLISAVSDK LRWRMKEEMD RAQAELDALK RTEEDLKKGH QKLEEMISRL
DQEVTEVDRN IDLLKRKDEE LSEALEKMEN QSENNDIDDV IVPTAPLYKQ ILNLYAEENA
IEDTIFYLGE ALRRGVIDLE VFLKHVRLLS RKQFQLRALM QKARKTAGLS DLY
//
