ID A0A3P8NB31_ASTCA Unreviewed; 1038 AA.
AC A0A3P8NB31;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=SEC24 homolog D, COPII coat complex component {ECO:0000313|Ensembl:ENSACLP00000001963.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000001963.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000001963.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000001963.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8NB31; -.
DR STRING; 8154.ENSACLP00000001963; -.
DR Ensembl; ENSACLT00000002007.1; ENSACLP00000001963.1; ENSACLG00000001362.1.
DR GeneTree; ENSGT00950000182924; -.
DR OMA; QNGAHAS; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000265100; Chromosome 3.
DR Bgee; ENSACLG00000001362; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0070278; P:extracellular matrix constituent secretion; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF6; PROTEIN TRANSPORT PROTEIN SEC24D; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 366..404
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 443..687
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 692..776
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 788..887
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 908..979
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 23..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..184
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 113427 MW; F1AFAAB0CAF0BFAF CRC64;
MSQQGYVAAP PYSQAQPGMG AYQGGFGSGP TQPLYGHYGG PPQAFSAPPA GMMKSSVAPA
ASMPLPAGSS QYNPNVQQNG SHPQSYPAPP AVSAPYGQPP HSLYNSMASP GPPPTQQLTN
QMSSMNLGSH VQGLQSPPPP ASSVVQQPFQ TPPPSTMAPP QMPPGLQSPH MSPLMSPPQS
PPESMPMASQ SMAGTSMAGM GRPFPGPPPP GPGGFQQPGL GSAGQPGYPQ QAGQFGGYMA
GPQQNMPGAF PGAQSAMAGP PQKKLDPDSI PSITHVIEDD QVKQGGQVFT TNIRGQVPPL
VTTDFTVTDQ GNASPRFIRC TTYSLPCTAD LAKQCQVPLA AIIKPFASLP KNETPLYVVN
HGDTGPVRCN RCKAYMCPYM QFIDGGRRYQ CGFCNCVNEV PVFYFQHLDH MGRRVDFYER
PELSLGSYEF VATLDYCKNN KPPNPPAYIF MIDVSYNNIK SGLVKLICDE LKTLLEKLPR
EEGMETSAIK VGFVTYNKVL HFYNVKSALA QPQMMVVSDT AEMFVPLLDG FLVNYQDSRA
VIYNLLDQIP DMFADTAESE TVFAPVIQAG VEAFKAAECS GKLFIFQSSM PTAEAPGKLK
NRDDKKLVNT DKEKTLFQPQ KGVYEQLSKD CVASGCCVDL FLFPSQYTDI ATMADVPSHT
GGSVYKYSNF QIETDGEHFL RDLRKDVQKS IGFDAIMRVR TSTGFRATDF FGGIYMNNTT
DVEMAAVDCD NGVTVEFKHD DTLSEETGAL MQCALLYTTI GGQRRLRIHN LSLNCSSQLS
ELYKSCETDS LINFFAKSAY RAILNQPLKN VREILVNQTA HMLACYRKNC ASPSAASQLI
LPDAMKVFPV YMNSLMKTAP LVGSTELSTD DRAHQRLSVM AMGVEDTQLL LYPRLIPLHN
IDVNSEKPAT PVRCSEERLT DSGIFLLENG QSMFLWLGQA SSPDLIQSLF NLPSLAHLQG
HMCALPELDN PLSRKVRSII SGLLEKRSNS MKLQIVRQKD KPEMLFRQFL VEDKGLHGGA
SYMDFLCYVH REIRQLLT
//
