ID A0A3P8NCK7_ASTCA Unreviewed; 1125 AA.
AC A0A3P8NCK7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Metabotropic glutamate receptor 5-like {ECO:0000313|Ensembl:ENSACLP00000002530.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002530.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000002530.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000002530.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8NCK7; -.
DR Ensembl; ENSACLT00000002586.1; ENSACLP00000002530.1; ENSACLG00000001674.1.
DR GeneTree; ENSGT01030000234595; -.
DR Proteomes; UP000265100; Chromosome 10.
DR Bgee; ENSACLG00000001674; Expressed in brain.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF165; METABOTROPIC GLUTAMATE RECEPTOR 5A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 580..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 578..840
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 1081..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 124872 MW; 7CC06DA35FCAE4D4 CRC64;
MIKNSILNAL FVEVGVNAQN NERRVLAHIP GDIIIGALFS VHHQPPADKV HERKCGAVRE
QYGIQRVEAM MHTLDRINAD PTILPNISLG CEIRDSCWHS AVALEQSIEF IRDTLVSSDE
EESQGRCTAE GGSMLLQGKK PIVGLIGPGS SSVAIQVQNL LQLFNIPQIA YSATSMDLSD
KSLYKYFMRV VPSDMQQARA MVDIVKRYNW SYVSAIHTEG NYGESGMEAF KDMAAKEGIC
IAHSDKIYSN AGEQSFDKLL QKLRGHLPKA RVVACFCEGM TVRGILMAMR RQRLVGEFVL
VGSDGWADRY DVTNGYQKEA AGGITIKLKS AYVTWFDDYY LNLKPDANLR NPWFPEFWQH
RFQCRLKGHP QESTAYNRTC TWRESLRHQY AQDTKMGFVI NAIYSMAYGL HAMQQALCPG
YKGLCESMRP IDGRKLLDFL MKTNFTGVSG EAILFDQNGD SPGRYEIMNF KQTGEDEYAY
IHVGSWDQGG LKMNDEEIWS NNSEIIQSVC SEPCQKAQIK VIRKGEVSCC WTCTPCKENE
FVFDEYTCRA CELGSWPTDD LTGCEPIPVQ YVRWGDPEPI AAVVFACLGL MATLFVTSVF
IKFWDTPVVK SSSRELCYII LAGICLGYLC TFSLIAKPHI VYCYLQRLGI GLSPAMSYSA
LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFLLI LLQLGIIVAL LIIEPPQVIY
DYPSIREVHL ICNLTTLGVV APLGYNGLLI LSCTFYAFKT RNVPANFNEA KYIAFTMYTT
CIIWLAFVPI YFGSNYKIIT MCFSVSLSAT VALCCMFVPK VYIMLAKPEK NVRSAFTTST
VVRMHVGDAK KAAKSGKSSS SMANLFRRRG STWGDTVDMS SNGKSVTWTQ NERGYRPNLW
KRMSFHVKKK DPVEANQTAI IKPFSKDGDT PADNGVKEQY EEPQLSQSFT YISIIGVGDI
GIGMIGGQTQ GTTIMDQISS VVNRFTANIS ELNTMMLPGG ATVSPPSTTA LPAATADTTA
CPPQYLAPRN RQTPSTVTTY AEVTAVSSFC ENRPAGKIYE HLAGTCVSSR RAKDMEELMA
LTPPSPFRDS SLSSNGSSPP SLSPASEAEY DQLLLRHYSQ SSSSL
//
