ID   A0A3P8ND81_ASTCA        Unreviewed;       643 AA.
AC   A0A3P8ND81;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Lamin-A-like {ECO:0000313|Ensembl:ENSACLP00000002689.1};
GN   Name=LMNA {ECO:0000313|Ensembl:ENSACLP00000002689.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002689.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000002689.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000002689.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   AlphaFoldDB; A0A3P8ND81; -.
DR   STRING; 8154.ENSACLP00000002689; -.
DR   Ensembl; ENSACLT00000002746.1; ENSACLP00000002689.1; ENSACLG00000001850.1.
DR   GeneTree; ENSGT00940000157244; -.
DR   OMA; IRQTEYS; -.
DR   OrthoDB; 72418at2759; -.
DR   Proteomes; UP000265100; Chromosome 22.
DR   Bgee; ENSACLG00000001850; Expressed in anal fin and 2 other cell types or tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR   PANTHER; PTHR45721:SF5; PRELAMIN-A_C; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF00932; LTD; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Prenylation {ECO:0000256|ARBA:ARBA00023289}.
FT   DOMAIN          25..381
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   DOMAIN          439..558
FT                   /note="LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51841"
FT   REGION          379..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          43..359
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        390..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  72204 MW;  4BC0BAF5C2D7A17F CRC64;
     MATPKNTPRG ANTPLSPNRI TRLQEKEDLC NLNDRLAVYI DKVRSLEVEN AGLRLRITES
     ETEVSRELTG LKAAYETELA DARQTLDSVA KERARLQLEL GKLREDHKEL KARNTKKESE
     LGGALQRLKD LEALLNSKDA SLTTALGEKR NLEVENRDLK AQVAKLDTSL ADAKKQLQDE
     MLRRVDGENR IQTLKEELEF QKNLHSEELR EIKRRHESRV VELDNGHQQE FECKLAEALA
     DMRNQHELQI KMYKDEIEKT YNTKLESARQ SADRSSHLVG AAHEELQQIR VRLESTSTQL
     SQLQKQLAAR EAKIRDLEDA LSRERDSTRR LLGEKDREMA EMRHQMQQQL DEYQELLDVK
     LALDMEICAY RKLLEGEEQR LRLSPSPPPT RAAGSRSSTS GALSRSIHHS AQNSPAKRRR
     PNDTDSEASS FAGGAVSRTR ITQQASASGR VTVDEVDLDG KYVRLSNKAD EDQNLGNWQV
     KRQVGSGTPI AFKFPAKFTL KAGQRVTIWA SNSGGTHNPP SDLVWKNQPS WGTGDLFQTT
     LISTNGEEMA MRKVTRTHLE EEDDDMQVAH STCGDGEYNL RSRTVVCGSC GLPSDKSSNC
     SVSSASRSFR SGGISEGLLP HSYVFSTSTP RKTGGRMESC PIM
//