ID A0A3P8NDD4_ASTCA Unreviewed; 4706 AA.
AC A0A3P8NDD4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSACLP00000002792.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002792.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000002792.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000002792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR STRING; 8154.ENSACLP00000002792; -.
DR Ensembl; ENSACLT00000002852.1; ENSACLP00000002792.1; ENSACLG00000001624.1.
DR GeneTree; ENSGT00940000154906; -.
DR OMA; HYEDTSD; -.
DR Proteomes; UP000265100; Chromosome 8.
DR Bgee; ENSACLG00000001624; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 3.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08709; Ins145_P3_rec; 2.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 3.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4042..4060
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4244..4265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4314..4336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4507..4528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4583..4606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..246
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 252..309
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 987..1183
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1316..1521
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3804..3830
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1314..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2322..2345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4090..4117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4196..4217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4095..4114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4706 AA; 535721 MW; A93D9A05ECDA63F5 CRC64;
ERMKEREGEK ENQRGEEMDD EVVLQCSATI HKEQQKLCLA AEGFGNRLCF LESISNSKNV
PPDLSICTFV LEQSLSVRAL QEMLANTQEK ADGVSYLCCL STSRSSTDKL AFDVGLQEDT
TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH LSYGNGSLHV DAAFQQTLWS
VAPICSGSEV AQGFLIGGDV LRLLHGHMDE CLTVPSGEHG DEQRTVHYEG GAVSCHARSL
WRLETLRVVW SGSHIRWGQP FRLRHVTTGK YLSMVEDKSL LLMDKEKADV KSTAFCFRSS
KEKLDLGVRK DVDGMGTPDI KYGDSVCYIQ HVDTCLWLTY QTVDAKCARM GGVQRKAIMH
HEGHMDDGLT LSRSQHEESR TARVIRSTVF LFNCFIRGLD ILRKKGRSFT LDLPIDSVSL
SLQDLIGYFQ PPGDHLEHED KQNRLRALKN RQNLFQEEGM ISLVLECIDR LHVYSSAAHF
AEAVGKEAGE AWSAILNSLY QLLAALIRGN RKNCAQFSGS LDWLISRLER LEACSGILEV
LHCVLVESPE ALNIIKEEHI KSIISLLDKH GRNHKVLDVL CSLCVCHGVA VRSNQHLICD
NLLPGRDLLL QTRLINHISS MRPNIFLGVS EGSAQYRKWY YELIVDQVLP FVTAEATHLR
VGWGNTNGYA PYPSGGEGWG GNGVGDDLYS YGFDGLHLWS GCIARTVSSP NQHLLRSEDV
VSCCLDLSVP SISFRINGQP VQGMFENFNS DGLFFPVASF SAGVKVRFLL GGRHGEFKFL
PPPGYAPCYE AVLPREKLKL EASQDQTATR DLLGPTVTLS QAAFTPIPVD TSQIILPPHL
ERIREKLAEN IHELWVMNKI ELGWIYGAVR DDNKRQHPCL VEFSKLPEQE RSYNLQMSLE
TLKTLLALGC HVGLADEHAV EKVKNMKLSS TYELSSGYKP APLDLSHIKL TSTQEAMVDK
LAENAHNVWA RDRIRQGWTY GIQQDLKNRR NPRLVPYALL DERTKKSNKD SLREAVRTLL
GYGYNLEAPD QDHAESGLSN VSAERFRIFR AEKTYCVNTG KWYFELEVLT AGEMRVGWAR
PGCLPDQELG SDDQAFVFDG FKVQRWHQGN EHFGRAWQIG DVVGCMVDLN EHTMMFTLNG
EVLLDDSGSE LAFKDFEVGE GFIPVCSLGV CQAGRMNFGK DVSTLKYFTI CGLQEGYEPF
AVNMNRDVTM WLSKRLPQFV PVPLHHQHIE VTRIDETIES CPCLKVTQKS FGSQNSYTDI
TFYRLSMPIE CAETRCPPNG SLFSPKRVTD TFCKTHINEL EDFENVSDFE VLMKSSHSHN
GPNGPDRDEF NNHKDYNQEK PSKLKQRLTL KRNKPDNSCP SSARVSEEVM ADDRVSSDFL
MQASTYYYSV RIFPGQEPSS VWVGWVTSDF HQYDPCFELH KVRTVTVTLG DEKGKVHESI
KRSNCYMVWG GESSSPTQGR NNGLEIGCLV DTTNGLLTFT ANGKELSTYY QVEPSTKLFP
AVFAKATSPN VFQFELGRIK NVMPLSAGLF KSEKKNPVSQ CPPRLHVQFL TPVLWSRVSN
HFLKVSVSRA NDRHGWLVQC NKPLQFMSLH IPEENRSLDI LELSEQKDLL KFHYHTLRLY
SAICALGNNR VAHALCSHVD EAQLLYAIEN KYMPGLLRAG YYDLLIDIHL SSYATARLMM
NNEYIVPMTN DTKSITLFPN EKKKHGLPGI GLSTSLRPRM HFTSPNFVSR PGPSCFNNGN
SGSGDCFQYS PEFPLDILKV KTIEMLTEAV REGSMHVRDP VGGSTEFLFV PLIKLLYTML
IMGVFQNGDL KNILRLIEPS VFCERRNKQD ALCMELEVLK KGEAEGGGKE GVLNVPKEGL
LEMKLPEPVK LQMCHVLQYL CDCQVRHRIE AVVAFSDDFV ACLQENQRFR YNEVMLALNM
SAALTAKKTK EFRSPPQEQI NMLLNFKDEK QECPCPEYIR EQLLDFHEDL MRHCGIELDE
ERGINCDSDF TIRGRLMSLV EKVAYLKKKM ANLPKEKKDR KPSTVQQLIS DTMVRWAQES
VIEDPELVRA MFVLLHRQYD GIGGQVRALP KTYTINSVSI EDTINLLAAL GQIRSLLSVR
MGREEEKLMI RGLGDIMNNK VFYQHPNLMR ALGMHETVME VMVNVLSGGD SKEITFPKMV
ANCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPS MRGSTPLDVA AASVMDNNEL
ALALREPDLE KVVQYLAGCG LQSCVMLVRK GYPDIGWNPV EGERYLDFLR FAVFCNGESV
EENANVVVRL LIRRPECFGP ALRGEGGDGL LAAMEEAIKI SQDPSRDGPS PMSESSKALD
MPGEEEDDTI HMGNAIMTFY SALIDLLGRC APEMHLIHAG KGEAIRIRAI LRSLIPIEDL
VGVISISFSM PNLAKDGLVV EPDMSAGFCP DHKAAMVLFL DRVYGIEDQN FLLHLLEVGF
LPDLRSAASL DTVALSATDM ALALNRYLCT AVLPLLTKCA PLFAGTEPFA SLIDSLLHTV
YRLSKGCCLT KAQRDSIEEC LLAVCGKLRP SMMQHLLRRL VFDVPLLNEH TKMPLKLLTN
HYERCWKYYC LAGGWGNFGV ASDEELHLSR KMFWGIFDAL SHKQYDQELF KLALPCLSAV
AGALPPEYME SNYMAMMEKQ SSMDSEGNFT PQPADTTNVT VPEKLDCFIT RYAEHIHEKW
CIEKFSNGWS YGDQMCEISK SHPLLKPYKS LSEKDKETYC WPIRESLKTM LSWGWSIDRI
REGDSVNLHN KPRRISQASQ LSFEGASAFS PRPTDMSNVT LSRDLQSMAE LLAENYHNIW
SRKKKLELEA RGGGNHPLLV PYDTLTAKEK SKDREKAQDI LKFLQINGYI VSRLSQELDT
PAIEKRFAYT FLQQIITYVD QAHQHMMEFG KNLLMPVRAT CLHHQPGCCV VLPLVDQYFK
NHRLYFLSTA IHPISSVLFS TVMKTGLESV KAALRSYFDS AAKDLEKTQE NLKLGQFTHS
RDQPRGATQI INYTTFALLP VLSSLFEHIG QNILPTDFVS LASVGDVQVS CYRILNSLFL
LGTNKSIYVV LPMLCSYMSH WWEHGPESDP DKANNCCTSV TSEYMNTLLG NILKIIYNNL
GIDEGAWMKR LAGKFFSQPI ISKAKPQLLK THFLPLMEKL KKKAAVVLMD EEHSKAEGRG
EMSETELLIM DQFTILVRDL YAFYPLLIRF VDYNRWLKES NPEAEELFRM VAEVFIFWAK
SHNFKREEQN FVVQNEINNM SFLITDTKCK MSKERKKMKR KGDRYSMQTS LIVATLKRLL
PVGLNICAPG EQELIALAKN RFTQLTTYFS RIIWLPDGKV HQLNIQFTEW FSLCLQVEHP
QRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPRHRAVNL FLQGYEKSWI ETEEHYFEDK
LIEDLAKPGE QEPSEEEEGQ KHKHIDPLHQ LIQLFSRTAL TEKWCSLVFS SFIFRWSAMI
CITFLTKEKE MEKQKLLYQQ ARLHDRGAAE MVLQTISASK GEMGPMVAST LKLGIAILNG
GNSTVQQKML DYLKDKKDVG FFQSLAGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGSGEK
VMQDDEFTCD LFRFLQLLCE GHNSDFQNYL RTQTGNNTTV NIIISTVDYL LRVQESISDF
YWYYSGKDVI DEQGQRNFSK AINVAKQVFN TLTEYIQGPC TGNQQSLAHS RLWDAVVGFL
HVFAHMQMKL SQDSSQIELL KELMDLQKDM VVMLLSMLEG NVVNGTIGKQ MVDMLVESSN
NVEMILKFFD MFLKLKDLTS SDGFKEYDPD GKGVISKRDF HKAMESHKHY TQSETEYLLS
CAETDENELL DYEEFVERFH EPAKDIGFNV AVLLTNLSEH MPHDTRLQTF LELAESVLNY
FQPYLGRIEI MGSAKRIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGEKEKMEL
FVNFCEDTIF EMQLAAQMSD AGERLSIKEE SEREKPDEEN PDVGFFSVTT VYMALLALRY
NIMLLIKKIK NMTVKDMVTT LVSTYWSVLL GLLHVAFNVA RGFCRIFYNT FIGENLVEGA
KTIKLLANMP DPTQDEVRGE GENREKRSDH SSTGEDLADL TVNTSETELL SDIFGLDLRR
EGGQYKITPH NPNASFTELL NSPMESKLES KCEPQKPSEY VKYFWNWIDD VEKQEKQSKN
ETMKPKMRRH HTSKSDEPDV QESAFLKKII AYQRKLLNYF ARNFYNMRML ALFVAFAINF
ILLFYKVTSS IQWDPLGGAT VDAKEEVMDQ TSMPQKPVTV RFVLEESSGY MEPMLRILAV
LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT
QSFPNNYWDK FVKRKVMDKY GEFYGHDRIS ELLGLDKAAL DFSDAHKKRK PRKDSSLNSV
DVKYQIWKLG VVFTDNSFLY LAWYMTMSIL GHYNNFFFAA HLLDIAMGFK TLRTILSSVT
HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGEL PDMKCDDMLT CYMFHMYVGV
RAGGGIGDQI EDPAGDEYEI YRIIFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK
EDMETKCFIC GIGNDYFDTV PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW
KMYQERCWEF FPAGDCFRKQ YEDQLN
//
