ID A0A3P8NDK5_ASTCA Unreviewed; 574 AA.
AC A0A3P8NDK5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002819.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000002819.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000002819.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR AlphaFoldDB; A0A3P8NDK5; -.
DR Ensembl; ENSACLT00000002879.1; ENSACLP00000002819.1; ENSACLG00000001867.1.
DR GeneTree; ENSGT00390000010463; -.
DR Proteomes; UP000265100; Chromosome 16.
DR Bgee; ENSACLG00000001867; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF52; GLUTAMINASE; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 116..198
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
SQ SEQUENCE 574 AA; 63867 MW; B9A060EC02FD1737 CRC64;
MLHFRSSTVL KELFEATLKR PFPVYREKTW LPTGSRCFCC LGATSVDARA TSAPLKLLNA
AAHRPALRTA PRAASLRSYC VKTEAEEVEE QLKKDGAGGE ADSDKRRNAG ILPSLEDLLF
YTVAEGQETI PAHKFLTALK ATGLRSGDPR LKECMETLKE TLKKTSDGVT LDRHLFKKCV
QSNIVLLTQA FRKKFVIPDF QSFTSHIDEL YENAKNLTGG QVADYIPQLA KFSPDLWAVS
LCTVDGQRHT VGDTKVPFCM QSCVKPLKYA VAVHDHSTEY VHSFIGKEPS GLRFNKLFLN
EDDKPHNPMV NAGAIVCTSL IKQSVSNAEK FDYVMNFLKK MAGNEYVGFS NATFQSERES
GDRNFAIGYY LKEKKCFPEG TDMTSVLDLY FQLCSIEVTC ESASVMAATL ANGGICPITG
ERVLNPEAVR NTLSLMHSCG MYDFSGQFAF HVGLPAKSGV SGGILLVVPN VMGIMCWSPP
LDKLGNSVRG IQFCTDLVEL FNFHNYDNLR HFTKKHDPRR EGGDQRQQTF GPMDYESLQQ
ELALKAPLWK KVSPAESNED SSTTVVYRMD KVIE
//