ID   A0A3P8NDN9_ASTCA        Unreviewed;       544 AA.
AC   A0A3P8NDN9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Mucolipin 2 {ECO:0000313|Ensembl:ENSACLP00000002901.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002901.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000002901.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000002901.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3P8NDN9; -.
DR   Ensembl; ENSACLT00000002966.1; ENSACLP00000002901.1; ENSACLG00000001939.1.
DR   GeneTree; ENSGT00950000183036; -.
DR   OrthoDB; 2877219at2759; -.
DR   Proteomes; UP000265100; Chromosome 15.
DR   Bgee; ENSACLG00000001939; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   CDD; cd21071; ELD_TRPML2; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF4; MUCOLIPIN-2; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        275..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        471..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          77..261
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          364..499
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
SQ   SEQUENCE   544 AA;  63158 MW;  AD162341F4FBB04E CRC64;
     MELFSRYLDR SNSVSSVITH DIMKEENLRD DLRYYFMSPC EKYRARRHIP WKMGVQILKI
     IMVTTQLVLF GLNNQLVVSY KEENTMALKH LFLKGYSGVD EDDYSVAVYT KHDVYESLFY
     VMDQYSQLGQ LSVGPISYAE DENGKLLPLT ICKEYYRRGS VEPSDEIYDI DAQLETVCMS
     HDPNTANLWR AENSSFFNLD FYRLVDIKIT FQLKGINLQT VRSRELPDCY SFFVTITFDN
     QCHSGKVKLF LDIDAESSAC RDWKISGTAQ KNTHYLLVFD AFVILMCLTS AVLCTRSIIL
     AVRLLQRFSR FFHENFNRKV CEDDQREFLN GWYLLVIVSD LFAIIGSILK MEIQAKNLTN
     YDVCSIFLGT STLLVWVGVI RYLGYFQKYN VLILTMKAAF PKVLRFCCCA GMIYLGYTFC
     GWIVLGPYHE KFEGLSLVAE CLFSLLNGDD MFTTFAQLKD KNTLVWLFSR AYLYSFISLF
     IYMVLSLFIA LITDAYETIK SYQKNGFPQT DLQKFLHEPT ELPNIEESDQ TDVSVRHSVL
     CYCQ
//