ID A0A3P8NDR1_ASTCA Unreviewed; 830 AA.
AC A0A3P8NDR1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Tuftelin-interacting protein 11 {ECO:0000256|ARBA:ARBA00015137, ECO:0000256|PIRNR:PIRNR017706};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002912.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000002912.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000002912.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC disassembly during late-stage splicing events.
CC {ECO:0000256|PIRNR:PIRNR017706}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR017706}.
CC -!- SIMILARITY: Belongs to the TFP11/STIP family.
CC {ECO:0000256|ARBA:ARBA00010900, ECO:0000256|PIRNR:PIRNR017706}.
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DR AlphaFoldDB; A0A3P8NDR1; -.
DR STRING; 8154.ENSACLP00000002912; -.
DR Ensembl; ENSACLT00000002977.1; ENSACLP00000002912.1; ENSACLG00000001959.1.
DR GeneTree; ENSGT00390000012739; -.
DR OMA; QNEFNPH; -.
DR OrthoDB; 3060898at2759; -.
DR Proteomes; UP000265100; Chromosome 12.
DR Bgee; ENSACLG00000001959; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000390; P:spliceosomal complex disassembly; IEA:InterPro.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR022783; GCFC_dom.
DR InterPro; IPR022159; STIP/TFIP11_N.
DR InterPro; IPR024933; TFP11.
DR InterPro; IPR045211; TFP11/STIP/Ntr1.
DR PANTHER; PTHR23329:SF1; TUFTELIN-INTERACTING PROTEIN 11; 1.
DR PANTHER; PTHR23329; TUFTELIN-INTERACTING PROTEIN 11-RELATED; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF07842; GCFC; 1.
DR Pfam; PF12457; TIP_N; 1.
DR PIRSF; PIRSF017706; TFIP11; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR017706};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR017706};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017706};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|PIRNR:PIRNR017706}.
FT DOMAIN 150..196
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 94356 MW; EBE44F7B3DB73899 CRC64;
MSMSHLYGRR DEEEEGVEVE SFEVTDWDLA NEFNPDRHRH RQTKEQATYG IWADRDSDED
ERPSFGGKRS KDYTVPVNFV SAGLRKTAAE EKQLKGEGGS DDSDDDGPAA PPPSRAPKKL
QMGNFRGNQS QRFAGGIQSG HGIGSWEKHT RGIGQKLLQK MGYQPGKGLG KNAQGIVNPI
EAKVRKGKGA VGAYGNERTQ QSLQDFPVVD SDEEEEKEFQ KELGQWRKDP AGSAGKKKPK
YSYRTADELR AKGKVAGRAT AASAGELAQV KVIDMTGREQ KVYYSYSQIS NKHSVPDEGP
PSMSTRDQKG SCFALPELEH NLQLLIDLTE QDILQSARRL QHEKDVVVSL SHESRALQNR
LDTEQDAIQR MEAVLALVER FPSGETPPGE GPTLQECARI FETLQTDYYE EYKMMGLADL
AVAVVHPLLK EKLHFWDPLK DSSYCLEDIG QWRAILESRD MHSSGPDSNM DPYHRLLWEV
WIPVMRTCVS GWQPRMVGPM VDCVEVWAPL LPLWILDHLL EQLILPRLQR EVDNWNPLTD
TVPIHSWIHP WLPLLQSRLE PLYPPIRSKL SNALQRWHPS DASARLILQP WKDVFTPGAW
EAFMVKNIIP KLALCLEELV INPHQQQMEP FHWVLDWEGM LSPSSLVSLL DKNFFTKWLQ
VLCSWLSNSP NYEEITKWYL GWKSMFSDVL LAQPLIKEKF NEALDIMNRA VSSGIGGYMQ
PGARENIAYL TQTERRKDFQ YEAMQERRDA ESVAHRGISA GVPTNFKDLI QAKAEENNIV
FMPLVAKRHE GKQLYTFGRI VIYIDRGVVF VQGEKTWVPT SLQSLIDMAK
//
