ID A0A3P8NDU1_ASTCA Unreviewed; 1034 AA.
AC A0A3P8NDU1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Mtr4 exosome RNA helicase {ECO:0000313|Ensembl:ENSACLP00000002942.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000002942.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000002942.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000002942.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8NDU1; -.
DR Ensembl; ENSACLT00000003007.1; ENSACLP00000002942.1; ENSACLG00000001921.1.
DR GeneTree; ENSGT00940000156183; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000001921; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 138..294
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 369..573
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 116668 MW; 653150B20A1F852E CRC64;
MADTFGDGLF SVFDDEQQNT TNKKVPSSVA AEPGKAAAKN ETDRDVGPSA RVKREADSDG
GEEVVFVKKP RHEAVSANEL NLAEFMPQVK VEQVETVEGC SHEVALPASE EYKPLKPRVG
KAAKEYPFVL DPFQREAILC IDNNQSVLVS AHTSAGKTVC AEYAIALALR EKQRVIFTSP
IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS EIMREVAWVI
FDEIHYMRDT ERGVVWEETI ILLPDNVHYV FLSATIPNAK QFAEWICHLH KQPCHVVYTD
YRPTPLQHYI FPAGGDGLHL VVDENGEFRE DNFNTAMQVL RDAGDSGGSS GGAKWDPKGR
KGGTKGPSSV FKIVKMIMER NFQPVIIFSF SKKECEAYAL QVAKLDFNRD DEKRLVEEVF
NNAVDCLSDE DKKLPQVEHV LPLLKRGIGI HHGGLLPILK ETIEILFSEG LLKALFATET
FAMGINMPAR TVLFTSARKF DGKNHRFITS GEYIQMSGRA GRRGMDDRGI VIFMVDEKMS
PAVGKQLLKG SADPLNSAFH LTYNMVLNLL RVEEINPEYM LEKSFYQFQH YRALPGVVEK
IKKLEEQYHT IEIPNEESVV TYFKIRQQLA KLSKEIQEFI HKPKYCLPFL QPGRLVKVKN
EDADFGWGVV VNFCKKTNVK TTTDSEPLYV VEVLVHCSKD SVKDAATEAA KPAAPGETGE
MQVVPVMLHL LTSVSSVRLY IPKDLRPYDN RQLMLKSIQE VQKRFPDGVP LLDPIDDMGI
KDPALKKVIQ KIEAFEHRMY THPLHSDPNL ESVYSLCEKK ALIAADVRTA KRDLKKARTI
LQMDQLKCRK RVLRRLGFAS PSDVIEMKGR VACEISSADE LLLTEMMFNG LFNDLTVEQA
TALLSCFVFQ ENASEMPKLT EQLAAPLRQM QECAKRIAKV SADAKLEVDE ESYLNQFKPH
LMDVVYAWAN GATFAQICKM TDVFEGSIIR CMRRLEEVLR QMCSASKAIG NTELENKFAE
GRKHIAPIFH LNEY
//
