ID A0A3P8NHE6_ASTCA Unreviewed; 1510 AA.
AC A0A3P8NHE6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Adhesion G protein-coupled receptor B1 {ECO:0000313|Ensembl:ENSACLP00000004216.1};
GN Name=ADGRB1 {ECO:0000313|Ensembl:ENSACLP00000004216.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000004216.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000004216.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000004216.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSACLT00000004304.1; ENSACLP00000004216.1; ENSACLG00000002608.1.
DR GeneTree; ENSGT00940000157432; -.
DR Proteomes; UP000265100; Chromosome 11.
DR Bgee; ENSACLG00000002608; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15251; 7tmB2_BAI_Adhesion_VII; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF39; ADHESION G PROTEIN-COUPLED RECEPTOR B1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1510
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018274394"
FT TRANSMEM 922..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..974
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 546..616
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 920..1161
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 292..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1294..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1462..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1510 AA; 166820 MW; 284AB254E0737503 CRC64;
MTSILLLVPG KARWPLPMLF LHIALFLLMR GCCHAAPSGP ESDLCSTVVQ SRFFGFFLSS
SVFPAVPCSW TLQNPDPRRY TIFIKVTKPT QHCMAQQLRT FQYDSFLETT RTYLGMESFD
EVVRLCDTSA PVAFLEAGKQ FLQMRKGHPR ADMAITEGNG DFKTEYLVVG KRNPSMAACQ
MLCQWLEDCL TSSTSNRPCG IMQTPCLCWD QPPLLSEGDS CYHNGVYLEN CLPSVKESGK
DVEINGGWSV WGQWAQCSSE CGGGIQTRIR TCRSPPEESY LCEGIVEEGR PCNSQSCTGK
GRHLSRSQSL RSVDSRKRDD ADKPRSGQQS SQTDSASGEE WSSWSVCSAT CGEGWQSRTR
FCVSSSYSTQ CSGPLREQRP CNNSAVCPVH GAWDEWSPWS LCSSTCGRGY RSRTRTCTPP
QFGGDPCEGP EKQTKFCNIA VCPVDGVWNE WSSWSSCSAS CSNGTMQRTR ECNGPSYGGA
ECRGEWLETV DCFLGECPVD GKWQTWSLWS GCSKTCGGGS QQRNRICYGP FFGGQPCPGE
REEVRSCNKK RCPEPHEICG EDNYSNVVWK MTPAGDTAAV RCPPNAMGLI LRRCTLDEEG
IAYWENPTYM KCISNDYRSI QTLTREHLSK AQRGLVGDGV SEVMTKLREI SSDGTSYSGD
LLAIVDVLKN MTEIFRRTYY SPSNEDTRNF VQSVSNLLME ENKERWEEAQ LLGPNIKELF
RLVEDFVDVI GLRMKDIQDM CEVSDNLVLS IHKRPVRGHG GISFPMKSWK CMVDWALSPE
NKVNISNNIL STGKPDPDDT STFVTGIALY RNLGSILNLQ RNSTVLNSRV LSVTIKPTPA
SLTVPFVVEF SHLYNGTTNH TCISWDESDS SSLLGSWSAR GCKTVLVDSF RTKCSCDRLS
TFAILARLNP EMNMDKTQLP SVTLIVGCGV SSLTLLLLII IYVSVWRYIR SERSVILINF
CLSIISSNAL ILIGQTQTRN KILCTLIAAL LHFFFLSSFC WVLTEAWQSY MAVTGRLRNR
IIRKRFLCLG WGLPALVVAI SVGFTKAKGY GTSSYCWLSL EGGLLYAFVG PAAAVVLVNM
VIGILVFNKL VSKDGITDMK LKERAGASLW SSCVVLPLLA LTWMSAVLAI TDRRSALFQI
LFAVFDSLEG FVIVMVHCIL RREVQEAVKC RVVDRQEDTN GDSGGSFQNG HAQLMTDFEK
DVDMACRSGT MKRSSLQGEE KASSGTLTLQ KGSNFNTMPA SMAKVHLQNV ADYTSHTLTM
RREKGATKGI STELPGAKSI YICDGELFKQ LDGDLPRGNG EGSSSEGAGK GPGYVILPTN
NTGTLKPSKG KEEQAAKYNI SIEQLPQTRL IHLANPVSGE PVPGFGLKSL PADQVSVSCS
DRDSPAHNLQ NMPRDSKVAN NMCDGGESGN SGVVSKSETV STLSMSSLER RKSRYAELDF
EKIMHTRKRH QDMFQDLNRK IHSADKDRES PPVDAKAAKR WSVSSASSDK TNMSVKSLNL
FCSAPSLPNI
//