ID A0A3P8NJH4_ASTCA Unreviewed; 769 AA.
AC A0A3P8NJH4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000004783.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000004783.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000004783.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A3P8NJH4; -.
DR STRING; 8154.ENSACLP00000004783; -.
DR Ensembl; ENSACLT00000004879.1; ENSACLP00000004783.1; ENSACLG00000003188.1.
DR GeneTree; ENSGT01080000257420; -.
DR OMA; EPQMPAM; -.
DR Proteomes; UP000265100; Chromosome 20.
DR Bgee; ENSACLG00000003188; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0002432; P:granuloma formation; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16856; STAT6_CCD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF66; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 553..653
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 149..218
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 769 AA; 88343 MW; 56332790EC0C7BFE CRC64;
MAQWIHMTQI LQHLPYETVS SLYPPNTFPI EVRHYISEWI ENQRWEDFSQ EKVEQESQAQ
ILLDQGISMM QSVAQQNANV VEKMKLMQMS RHMELFHQQP LKFALMVRDL LRQERALING
TSPAQYPAYP TNDMSKQDVD QLVLKVLEVQ EIRKKMHQIQ EELNWERQNF ESAHSQGSFQ
QNGLDSANAE IKKLQTHIQQ LEYNIQAMAT KRSQLLKESM ELLGICQNRF LNRLNEWRWE
QRKAAIGFPF DDNLSPLQTW AEQLLGMNGN LRQELMLTGE LTSELQEGLS QLVQVLIESS
LIVDKQPPQV IKTQSKFSTT VRYLLGEKVA PGKPVLVKAQ IINEIQARNL ANVHGDNVGE
LINNSAVLEH NAATKSTCSN FRNMSIKKIK RADRKGSESV TEEKFALLFS SEINITGCET
PYRIQVISQP VVVIVHGSQD NNAVATIIWD CAFSERDRVP FVVPDRVPWR MMYNTLNSKF
TSEVGTQHNL DQYNQHFLAQ KVFDKPDFNE DFSNMMVSWA QFNKEVLPGR PFTFWQWFEG
VMELTKKHLK TYWSEGLIFG FIGKQHLHLI LKDRPNGTFL LRFSDSEIGG ITIAYVSATE
NGGQKIQNIQ PFTKRDLEIR GLGDRIRDID HITYLYPEFP KHDVFRKFYT EPTSSTNEGY
IPVSLQLKVG MDAQRPTSST PSSFNMDTMP SLHSSFNVEP IAPAPIVQGP ETSQSSFSMQ
QFPSPFNSSE FSDEIIDGAT TAPGLEPMYV FFFFWVNFCK TSIAMVTDY
//
