ID A0A3P8NJL3_ASTCA Unreviewed; 1906 AA.
AC A0A3P8NJL3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase F {ECO:0000256|ARBA:ARBA00044158};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000004949.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000004949.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000004949.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSACLT00000005046.1; ENSACLP00000004949.1; ENSACLG00000003205.1.
DR GeneTree; ENSGT00940000155060; -.
DR Proteomes; UP000265100; Chromosome 15.
DR Bgee; ENSACLG00000003205; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14629; R-PTP-F-2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1906
FT /note="Receptor-type tyrosine-protein phosphatase F"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018023640"
FT TRANSMEM 1262..1285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 136..231
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 328..419
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 423..517
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 521..611
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 616..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 818..911
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 916..1008
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1013..1101
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1351..1606
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1526..1597
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1638..1897
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1815..1888
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1906 AA; 213073 MW; A872B9C16EDF94A1 CRC64;
MDLRFRRLSP LTRAALHLLL LARLVLPSHT ESTPSFIKSP EDQTGISGGV ASFVCQAVGE
PKPRITWMKK GKKVSSQRFE VIEFDDGSGS VLRIQPLRTH RDEAIYECTA TNSVGEINTS
AKLTVLEEDQ IPHGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEIYWF KDFLPVDISS
SNGRIKQLRS GGTPIRGALQ IENSEESDQG KYECVAVNSA GTRYSAPANL YVRVRRVPPR
FSIPPTNHEV MPGGSVNLTC VAVGAPMPYV KWISGEVELT REDEMPIGRN VLELTNIRQS
ANYTCVAISS LGMIETTAQI TVKALPKMPT SLTVTETTAT SVTLTWDSGN PEPVSYYVIQ
YRAKLSENGF QEVDGVATTR YSIGGLSPFS EYEFRVMAVN NVGRGPSSSI VDTRTSEQAP
SSPPLHVQAR MLSSSTMLVQ WEPPEEPNGQ IRGYRVYYSS DHDAPLSAWQ KHNTDDSHFT
TISGLATDIT YSLRVLGFTS VGDGPPSDTL QIKTRQGVPA QPSDFDGEAE LDSRIMLSWL
WPVQEPIISF ELVYWEANNP TDKHRVTFDA AGSYAVDGLK PDTLYVFSLA ARSEMGLGVF
TQPIECRTAQ STPSAPPQEV HLLSLSSTSV EVRWVAPPTD SQHGEIVGYS LAYQALTGED
QKRHQVSGIG PDITSYILED LEKWTEYLVW VRAHTDVGPG PESSAAKVRT KEDVPGAPPR
KVEVEALNST ALRVSWKPPL SVKQHGQIRG YQLVYSRLEN GEPHGQPVIL DVNLPEAQEA
FIAGLLPETT YSVTVAAYTT KGDGARSKAK VATTTGAVPG KPTMMISTTI GNTALIQWQP
PKEMVGEHMG YQLQYKRAEE EAFTIKHFKK TDDHFTVTGL HKGAVYIFKL CAKNRAGNGE
EYVKEISTPE DIPSSYPQNL SVVGLTATST KLAWDPPPLA ERNGKIVKYV VMYRDINSPN
NSTNVTTDTQ MTVYGLQPDT TYDIRVQAFT SKGGGPISPS IQSRTMSTSM PDLPSVFTKN
FGVKAVTKTS VLLTWEVPET YKSQVPVKIL YNQQSVEVQG NLKRKLITQL QPDTDYSFVL
MSRGNSAGGL QQQVSIRTAP DLLTVKPAQH HIDVEEGGKV TISLPKVPDA AAVRWYYIVV
VPVTPVSLRR WENPEDMDIQ ELLESGADSS LQRRKRQSND FLQPYIAAKL DTLPEIFTLG
DEKKYSGFYN KPLPGQQQYR CFVLADLTDH ESQRTFAASP FSDPFTVKIS GVIRQPQEDP
EMLWVMGPVL AVILIIIIVI AILLFKRKRT SPAKDEHMAG VKDSLLAHSS DPVEMRRLNY
QTQGMREHPP IAVCDLADHI ERLKANDGLH FSQEYESIDP GQQFTWEHSN LEVNKPKNRY
ANVIAYDHSR VILTPVDGVP GSDYINANYI DGYRKQNAYI ATQGPLPETL SDFWRMVWEQ
RTCTIVMMTR LEEKSRVKCD QYWPSRGTET YGMIQVTMLD TLELATYSVR TFALYKNGSS
EKREVRQFQF LAWPDHGVPE YPTPTLAFLR RIKSCNPQDA GPMVVHCSAG VGRTGCFIVI
DAMLERMKHE KSVDIYGHVT CMRAQRNYMV QTEDQYIFVH EALLEAAVCG NTEVPARNLY
AHIQKLTQVA AGEAVTAMEL EFKKLANSKA HTSRFISANL PCNKFKNRLV NIMPFESTRV
CLQPIRGVEG SDYINASFID GYRQQKAYMA TQGPLAETTE DFWRMLWEHN STIVVMLTKL
REMGREKCHQ YWPAERSARY QYFVVDPMAE YNMPQYILRE FKVTDARDGQ SRTIRQFQFT
DWPEQGVPKT GEGFIDFIGQ VHKTKEQFGQ DGPITVHCSA GVGRTGVFIT LSIVLERMRY
EGVVDLFQTV KTLRTQRPAM VQTEDQYQLC YRAALEYLGS FDHYAT
//
