ID A0A3P8NKQ6_ASTCA Unreviewed; 454 AA.
AC A0A3P8NKQ6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Orexin receptor type 2 {ECO:0000256|ARBA:ARBA00015322};
DE AltName: Full=Hypocretin receptor type 2 {ECO:0000256|ARBA:ARBA00032358};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000005396.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000005396.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000005396.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8NKQ6; -.
DR STRING; 8154.ENSACLP00000005396; -.
DR Ensembl; ENSACLT00000005512.1; ENSACLP00000005396.1; ENSACLG00000003616.1.
DR GeneTree; ENSGT01070000253744; -.
DR OMA; EWDKFVP; -.
DR Proteomes; UP000265100; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016499; F:orexin receptor activity; IEA:InterPro.
DR GO; GO:0022410; P:circadian sleep/wake cycle process; IEA:InterPro.
DR GO; GO:0007631; P:feeding behavior; IEA:InterPro.
DR GO; GO:0030186; P:melatonin metabolic process; IEA:Ensembl.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IEA:Ensembl.
DR CDD; cd15208; 7tmA_OXR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000204; Orexin_rcpt.
DR InterPro; IPR004060; Orexin_rcpt_2.
DR PANTHER; PTHR45695:SF24; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45695; LEUCOKININ RECEPTOR-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF03827; Orexin_rec2; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01064; OREXINR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..394
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 454 AA; 52087 MW; 65F98E3D21AD3256 CRC64;
MSGITGNVDC EECLSSGHLP NSTELHVHPT LDDDEELLRY IWREYLHPKQ YEWVLIVAYI
IVFFVSLIGN SLVCFAVWKN RHMRTVTNYF IVNLSLADVL VTIICLPASL VVDITETWFF
GNTLCKIVPY LQTISVSVSV LTLSCIAQDR WYAICHPLLF KSTAKRARKS IVVIWVVSCI
IMIPQAIVME CSSLLPELTN KTSLFTVCDE HWGAEIYPKV YHTCFFIVTY FAPLCLMVLA
YIQICHKLWC QQVRILPFAI NINFPMGFQG LMCACIHFNV FIQQIPGSTS VLQRKWKSIK
CSAPTPGPGE SVRVRTSTVC AEIKQVRARR KTARMLMVVL FVFALCYLPI SVLNVMKRVF
GTFKKTNDRE TVYAWFTFSH WLIYANSAAN PIIYNFLSGK FREEFKSAFS CHCCGQHENE
TRRIRTRTRT DSRKSLSTQV HNVDNVSRIS DQMV
//
