ID A0A3P8NL64_ASTCA Unreviewed; 1008 AA.
AC A0A3P8NL64;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like {ECO:0000313|Ensembl:ENSACLP00000005555.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000005555.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000005555.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000005555.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8NL64; -.
DR STRING; 8154.ENSACLP00000005555; -.
DR Ensembl; ENSACLT00000005674.1; ENSACLP00000005555.1; ENSACLG00000003742.1.
DR GeneTree; ENSGT00940000165482; -.
DR OMA; SSFKKCV; -.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000003742; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11821; SH3_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR035836; ASAP1-like_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF5; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2 ISOFORM X1; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 301..393
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 419..540
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 580..615
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 616..648
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 946..1008
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 702..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..811
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 112832 MW; FC40CD294EC5E9BF CRC64;
MPECVSVSEF VQEVQEDWNS PTTSSFTSKM ISCRNTVYLL EEVLDSDRLV LQKMKKAAKA
KYTSGQEHVS HLEQYINAME KLSVNCHSNG ETEVGSAFCR LADFSKELLS PMKNLLKSML
HNINFFLDSL VKGDLREVKG DLKKPFERAW RDYESRFKQV EKEKRELARQ YGMVRSEVSG
GEIAEELEKE RRSFQLSMCE YLIRVNEIKT KRGVDLLQNL IKHYHSHNNF LQECVSTTQR
LKQYMDELNG VLTTVKQRQD EEKRQLCTLR DQLRPVVHTE QDSLPKQVYN MHQLLGDKQY
GTERTGFLYK KSDGLRKMWQ KRKCSVHNCY LTIAHATPNK PPTRLNLLTC QVKPSVEDKK
CFDLISHNRT YHFLAEDEAE CVAWMSVLTN SKQEALSMAL DGGRKGGGGS ESSVEDLTRA
ITDDIKRMPG NNSCCDCGAP DPGWLSTNLG ILTCIECSGI HREMGVHVSR IQSLSLDSLG
TSDLLLARNV GNSGFNEILE ANLLSPSLKP SQHSHMPERK DFILSKYQDV NFVRRSHSST
SALRLRLQEA TKSCDIYTLI QLYAQRAELS QPLHAHIQEK GETALHLAVL LADRTSLHIL
DFLAQNCSNV DTQTSAGNTA LHYSCLHNKT DCVKLLLRAR ANTHIKNELG ETALDVSRRL
KHTHCEALLQ KAQSNQFDHH VHVEYEWRIR HDDLYDSDDD FDDKNGPLKK ERSTSSSSSS
FTPSFSFSSR PFSFSQSNSS CVTLSSSGTP GGPAGGLLSV GRRLAMAMEL HSHPAGSVPS
PPPPPPSSPA PPLPPRVKAP NVPPPPPPSG GDGMGEEEEG EGEVFFPLTG NRRITPPSPI
AVRHKRSCSE SSKHDYGLPA SPRIYSGPDS SFRKCVPASP LSSLTERSDR GFRRADSESG
SSHFQILNSK APINGSPSNQ RSQSFESESR GSAPQPLPRR SLPRGASSRR VQALYDCQAD
HHDELSFSEG QVLVVLGQED NDWWHGYIEE EPDQRGLFPS SFVQPLSD
//
