ID A0A3P8NMI6_ASTCA Unreviewed; 375 AA.
AC A0A3P8NMI6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Growth differentiation factor 11 {ECO:0000313|Ensembl:ENSACLP00000005848.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000005848.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000005848.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000005848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3P8NMI6; -.
DR Ensembl; ENSACLT00000005976.1; ENSACLP00000005848.1; ENSACLG00000003939.1.
DR GeneTree; ENSGT00940000166043; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000003939; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19388; TGF_beta_GDF8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF166; GROWTH_DIFFERENTIATION FACTOR 11; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..375
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018312009"
FT DOMAIN 263..375
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 375 AA; 43316 MW; 566053261F7BAADA CRC64;
HDKAKFFCFV LLLLLLFNMC YLSFKQRVKE EDAGSHECSA CVWREQSKVL RLETIKSQIL
SKLRLKQAPN ISREVVNQLL PKAPPLQQLL DHHDFQGDAS SQDEFMEEDE YHATTESVIT
MASEPEPLVQ VNGKPSCCFF KFSPKLMFTK VLKAQLWVYL RPLQQTSTVY LQILRLKPVT
EQGSRHIRIR SLKIELNSRV GHWQSIDFKH VLQNWFKQPH TNWGIDINAF DESGNDLAVT
SLRPGEEGLQ PFLEVKVLET TKRSRRNLGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
PKRYKANYCS GQCEYMFMQK YPHTHLVQHA NPRGSAGPCC TPTKMSPINM LYFNDKQQII
HGKIPGMVVD RCGCS
//
