ID   A0A3P8NND8_ASTCA        Unreviewed;      1077 AA.
AC   A0A3P8NND8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000006307.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000006307.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000006307.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   AlphaFoldDB; A0A3P8NND8; -.
DR   STRING; 8154.ENSACLP00000006307; -.
DR   Ensembl; ENSACLT00000006450.1; ENSACLP00000006307.1; ENSACLG00000004266.1.
DR   GeneTree; ENSGT00390000011669; -.
DR   OMA; CERCVWT; -.
DR   OrthoDB; 5490899at2759; -.
DR   Proteomes; UP000265100; Chromosome 17.
DR   Bgee; ENSACLG00000004266; Expressed in anal fin and 6 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd22095; F-box_FBXO18; 1.
DR   CDD; cd18786; SF1_C; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          224..278
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1077 AA;  121757 MW;  D9B3852CACF9C604 CRC64;
     MEVSVKGKAK RRHLNAEDCD GLGQRAVLTR PHTFNQRMGN RDPNRGLYPR TPTKRPKFAP
     ATGSPSGRQK GINEFFSVAR VLSSSPHKSS LPSTSKEEPR AAEEEEDEDD DISLLAVPLA
     PQLRVTEEEE IDDSLLAAVM MPEPEAGEEE EIDDASLLAV EMMPQSKVKE EQQVDYLEGM
     TAEMFGNDDE FDQCDIDNEE EEVEALPDAH FGLLGSRSGL LKPQGCMDDL PEEVLREVLC
     LLPAQDLYLN VRLVCHRWRN IVQDSTFVPF KKQYYRYMMR ERHTEMEICS ILRNSGITGP
     APSEHSIRKL VVLMAQHKVG ERLRPDEVLE RVKKHRLFPQ AEASIRLRIS DVQKHFNLGI
     TGPNPYAAMA VILILSEGVG DVQALVSLLT GCMSHSAITE YLCHMAMMLL ALERNKVTVS
     NRLHYNIYYV LHLMENGPFP VSSPQSRRPQ IHLTQEQQQI LSHNIQDDHV VKIIAFAGTG
     KTTTLVKYAE QRPDLRFLYV AFNNSVASEA RRRFPRNVDC KTVHSLAYND VGKRYKFRDK
     LTFNMKAFAI SSVLPKGRGG FTKAKVVMTT LNAFMASTDE TITIRHVPNS RVTKNNFRKD
     IDHDEKLLVV RDAQRIWKKM KDLNEKSKDA YYMTHDGYLK LWQLQDPKPC LSGAYNALFI
     DEAQDCTPAI MDVLLSQSCG KILVGDPHQQ IYTFRGAVNA LNVVEHTHIY YLTQSFRFGA
     EIAYVGATIL KVCKGVQKIL VGGNQKGGVC DNAADRVVEA VGAGACQSRG KTAILSRCNF
     GVFSEAVRLT DANPSCRLHF IGDIKNIGLD RIMDVWHLLQ QTGQQLQEGE RRPHYIRDPL
     IRSFASRRSE NPFFAFKKYV EQTEDNELQA KVTIVEKYRK RIPELVARLK ACSENDLCNA
     DFIVGTVHKS KGLEFDTVMV TDDFVKVPCS KHNLRHSPEF SFAKIPDDEW NLLYVAVTRA
     KTTLIITKNI RRIITMAGEY FFRSEMPSSL LKSDQPLPCS IANCPNCITP GSAFIMCRQQ
     MRCTDGLSQG GPLCEKCVWT RVGPIAFLMT EDVLSMAEIP QRLDLPVHHA FFLELFF
//