ID A0A3P8NNK3_ASTCA Unreviewed; 492 AA.
AC A0A3P8NNK3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000006365.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000006365.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000006365.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR AlphaFoldDB; A0A3P8NNK3; -.
DR STRING; 8154.ENSACLP00000006365; -.
DR Ensembl; ENSACLT00000006510.1; ENSACLP00000006365.1; ENSACLG00000004292.1.
DR GeneTree; ENSGT00950000183157; -.
DR OMA; CTAKAPG; -.
DR OrthoDB; 5484756at2759; -.
DR Proteomes; UP000265100; Chromosome 6.
DR Bgee; ENSACLG00000004292; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF23; FASCIN; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682}.
FT DOMAIN 23..133
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 142..253
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 266..374
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 389..492
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 492 AA; 54610 MW; ACA8EDDAB1BCC665 CRC64;
MSSNGADGDL LQIPLGLINS EGKYLTAETF GFKINASASS LKKKQTWTLE QTGEDDSAVF
LLSHLGRYLA TDKDGNVTAD SETRERDCRF VITVHEDGRW SLQSEPYGRF LGGSEDRITC
FAQTASPAER WSMHLAVHPQ VNLYSFARKR FAHLSARQEV SIDRDVPWGV DSLVTLVYRD
QRYHLETSDN RFLRNDGNLS TATDKDTGYM LEFHSGKVAF RDCNGRYLAP VGPTGTMKSG
RSTRVGKDEQ FGLERSHAQV VLTAGNERNV STRQGMDLSA NQDEEGDQEV FQLEMSREDR
KCAFRTAAGK YWTLTATGGL QCTASTKSAN SYFELEWRDG RVCIRAANGK YVTAKKNGQL
AATIDSAGEA EQFLMKLINR PIIVLRGEHG FIGARKAGTA TLDSNRASYD VFQLEFHNGA
YSFKDSQGKY WCFGDGTAIV CGDSSPVQFL LEFCDLNKMA IRTLRGKYLK GDHAGGLKAS
ADSLESATLW EY
//
