ID A0A3P8NP04_ASTCA Unreviewed; 5000 AA.
AC A0A3P8NP04;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=SCO-spondin {ECO:0000256|ARBA:ARBA00020523};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000006515.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000006515.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000006515.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR STRING; 8154.ENSACLP00000006515; -.
DR Ensembl; ENSACLT00000006664.1; ENSACLP00000006515.1; ENSACLG00000004148.1.
DR GeneTree; ENSGT00940000155829; -.
DR OMA; QTKNELC; -.
DR Proteomes; UP000265100; Chromosome 9.
DR Bgee; ENSACLG00000004148; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00112; LDLa; 11.
DR CDD; cd19941; TIL; 12.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 13.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 25.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF396; SCO-SPONDIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 10.
DR Pfam; PF01826; TIL; 10.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 23.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00192; LDLa; 13.
DR SMART; SM00209; TSP1; 27.
DR SMART; SM00214; VWC; 9.
DR SMART; SM00215; VWC_out; 13.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 12.
DR SUPFAM; SSF57567; Serine protease inhibitors; 14.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 25.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 13.
DR PROSITE; PS50092; TSP1; 26.
DR PROSITE; PS51233; VWFD; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..5000
FT /note="SCO-spondin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018247492"
FT DOMAIN 171..332
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 958..1128
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2076..2218
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 4906..4993
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 1322..1334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1329..1347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1372..1387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1396..1408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1403..1421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1436..1448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1443..1461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1455..1470
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1472..1484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1479..1497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1491..1506
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1512..1524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1519..1537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1586..1601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1656..1674
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1668..1683
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1699..1717
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2252..2267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2287..2299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2294..2312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2306..2321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2337..2349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2344..2362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2356..2371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 5000 AA; 541317 MW; 1F8DBE165911B762 CRC64;
MLGWAWFPNW IMTRAWRGGL ACPRTQERVE QVLSPRLQLE VRCSEVYQYN TQGWRLDVDR
MRVKHGGDDG IALYYKQQGS EASCFMYKPP EIQSQMLNKT ARACCEGWAG PRCSEAVGVR
GQCYSTWNCV EFPGVHNSSL MPMEQCCSTL WGLSWRNKPC TYVASVPQSS ATCMSWGGVH
YRTFDRKHFH FQGSCTYLLA SSTDGTWAVY ISTALRMMLG LDLVAVHRRN LTLNNLHIPN
GQPLFQNGVS VHWLGDFVFV ESGLGVRVKF DLVNTVYLTV TAEHMAATRG LCGIYNNNAD
DDFTTTGGSV SQYAASFGNS WKVPDQHSEG CSDAAELGHS CDVTGDTALR QEAESVCRRL
LENPFTHCHP QLDPAAYIDT CLYLFCSLPA KEREGAVCDT LASYARECAQ QHIILMWRTP
TLCDRVCPRG QVFSDCISSC PPSCTSPQPP AAMGQCRDEC VGGCECPPGL YFHQGRCLKR
DDCPCFHRRR TYQSGDKIQQ RCNTCVCSSG QWQCTGEKCA AECALMGGLQ VTTFDKKRYS
LQGSDFVSVR CGECTAGGGE GGGGCLKEMS VTALRTTKEA VPLVTGDLAV LKASSSFLLI
QMFGAQILWY LDGPLAFITL QPGFGNKVRG LCGTLTWNQR DDFTTPEGDV ENSVTSFVAK
FTTALCTLPG GAAPEACSTY TQRRQYAETV CAVLHSPIFQ LCHDVVEREP YFRLCLSEVC
SCVPQGSCHC TVLTAYARHC AQEGVVVQWR NRTFCTMQCS GGQVYQECGR TCGNSCSDLR
HSWSCDDSRS QSLCVPGCQC PPGLVQDQQG QCVPISLCPC MQGAVMYSPG AMVQNNCNTC
VCEQGLFNCT QELCEEVNQC PGTLVYSPRS CLLTCSSLDP PGQQQGSSVM QSSCREPLSG
CVCPQGTVLL GDRCVLPDEC PCHHNGRLYY SNDTITKDCN TCVCNERRWH CGRSACAGVC
VATGDPHYVT FDGRCYSFLG DCQYVLARET SGLFSVTAEN VPCGSTGVTC TKSVTLSLGN
TVIHLLRGNA VTVNGMPVSL PKSYSGSGLT LEKVGLFVSL SSRLGVTLLW DGGMRVYVRL
AAHLRGRVGG LCGNFDGDTE NDFTTRQGIV ESTAELFGNS WKVSPSCPDV ADQDLRDPCA
LNSHRVTWAR KKCAVLTQGL FSRCHPEVPF QQYYDWCVFD ACGCDSGGDC ECLCTAIATY
AEECNRRGVY IHWRSQELCP LQCDNGLVYD PCGPACSRSC PTIQQGPHSS CDAVSCVEGC
FCPAGTVRHG DSCVAPSQCP CEWDGSLFPA GAAVTQHCQN CSCEEGVWKC DGVACPPPSP
PCLESEFTCA GGRCIPTQWV CDNEDDCGDG SDEILNEPQP CSGPCLNLAL RCDGHPDCAD
QSDEDFCGPA TPVPLCPPGE FQCANGKCLP ASRVCDGWLD CGFADGSDEQ DCGVVCDEGE
FLCAGGRCIL YLHRCDGHND CGDLSDERGC VCAPGEFQCR GDQCVPADRV CDGTKDCPSG
SDEAVCPSKV TCAPDQFACG DGTCVAITKL CDGATDCSGR EDENRTNCFT STTTPSLLPV
TPTSACRSYE FSCATVGQCV PQAWRCDGET DCMDGSDEQQ CGAPCGSGQV PCVSGDQCVE
YQQLCDGTPH CRDTSDESID NCGSTRIPPC LGSFPCDNRT CVNMSQVCNG VPDCPRGEDE
LVCALPGSNT TVTCSEFTCM DGTCVPFNVV CNGVPDCPDS SLGSLGDPTD EQGCKTWSSW
GPWSPCSTTC GTGFMSRERS CPPGDLLHHC RGQDIQRQEC FNTTCPVDGR WLPWGSWSNC
SSGCGGVQVR NRACTPPLYG GQDCSQLPGP SNLSMETKPC LNDGCDNTSC PTGLVRHSCA
PCPLSCAHIS SESTCDPRCW CPEGQVMSHT QQCVSPEECV CEVAGVRYWP GQQIKVDCEV
CVCETGRPQR CQPNPDCSIH CGWSSWSEWG ECLGPCGVQS VQWSFRSPNN PPKHGDGRTC
RGIYRKARRC QTAPCEECEY HGQSHTVGDR WRSDQCQLCR CLPNLTVQCS PYCPYAATGC
PQVRGCVWLL FIFVGKSASV LNHANFVYPC SCLEECWSPL GVQSLPASSF SASSQQAGHP
PDAARLHAWD PHSDLQRRPD SYTGNTQSPY IQIDLLKPYN ITGVLTQGGG VFGTFVSSFF
LQFSRDGNQW YTHKELVTDA PPRAKVQQLD RIVSAQFVRL LPHDFQNGIY LRLEIMGCGT
QPSTTATSPR SCPAGQFSCP PPGGCIEAWK RCDGNPHCPR GEDESGCHPH DNITAHPRDT
GSPRVICVQG QFACGSFGCV DSAQVCDGIR HCLDGSDEQH CGAPAVTPQR PTVPSPCSPK
QFSCDSGECV HLDRRCDLQK DCVDGSDEKD CVDCVMSPWT AWSACSVSCG LGSLFRQRDM
LREALPGGAC SGDPFDSRAC FPQACPVNGH WSEWTEWSEC DARCGGGVSQ RNRSCSAPPP
KNGGRDCEGM TRQSQSCNSQ PCTKDTDTQT GCVRGMVVVT EEDCQAGRVD PCPPTCSHLS
LDRNCTAECI SGCRCPYGLY LQQGRCVNSS QCVCHWDGQT LHPGQVVPRD QCTTCKCRDG
QVTCDRSSCV ATCHWSAWSS WSPCDVTCGL GLQQRYRSLP AGAVRGQPCP GDSSEAQSCS
STCFPALPGG TWSKWTGWSE CSKTCFNHVD DVGVRRRFRS CTPFNHTQPA CDGDSEEQEP
CNTEHCPVPG GWSAWSAWSQ CSSRCDSGVQ TRERLCNSPT PQHGGKSCSG PHIQTRDCNS
QPCSGVCPEG MTYMTVRECE AQGGACPRVC LDMTSTEVQC ATTCYDGCYC APGFYLLNSS
CVPLAQCPCY HQGEMYPAGA TLPVDACNNC TCTDGEMQCG TAPCPVDCGW SSWTQWSACS
RTCDVGVRRR YRSGTDPPPA FGGRPCKGDR VGIDTCSIEP CLKEPWSPWS ECSVTCGGGY
RTRTRGPIRI HGTTQQFSTC NLQPCGNTGT CPPGQEWMQC MMGAVSCMDL TLDLSRNCTP
GCRCPRGTVQ QDGVCVSESD CRCDVGGEQY NPGDTVPLDC SNCTCEGGRL VTCSRFSCNV
DGQWSAWTPW GHCSVSCGAG LQSRYRFCSS PRPSGSGLPC TGPHHEDQVC IIAPCDLAPC
SQVPGTVFSS CGPSCPRSCD DLTHCEWHCE PGCYCTEGKV MSANGTVCLE KEDCPCLDLN
TGRRLEPGDT IEAIDGCNNC TCEGGKFNCT RNPCPVSGGW CEWSEWTPCS RTCGAESVTR
YRSCSCPEPE AGGEPCSGEQ ELHSGVGVQI HRQPCPSVPG CHVDGGWSRW SPWSRCDKRC
GGGRSIRTRS CSSPPPKNGG KKCAGEKNQV KPCNTKPGCP PGQEFVMCAS QCPQRCSDLQ
QGIECQTNSE CQPGCRCPQG QLQQDGVCVQ LWQCDCVDSL GQIWVAGSTH QVDCNNCTCS
DGQLLCSNDS CQATLDGAWT PWSVWSDCSA TCGRGTHVRT RACINPPPRN NGSHCSGPEK
ETQDCQTPPC LEWTEWSECD ARCGGGVRQR NRSCSAPPPK NGGRDCEGMT RQSQSCNSQP
CVCPVGMTYM TVRECEAQGG ACPRVCLDMT STEVQCATTC YDGCYCAPGF YLLNSSCLAP
PCLLINVLLL SPSVSVFSCL MVCCVHGRWN CSLEHCPVHG ALSSWGPWSP CSLSCGGLGL
KTRSRGCTQP APARGGRDCQ GPRRETTYCQ APDCPATVVP TEEPATPEED SGFSPWSPWS
PCTKTCTDAL SPALKSRHRQ CVTPACSGSS HQEKACNLPQ CPGTPQAECA RRNCSWTKWA
EWSACSRSCG VGQQQRIRTF LSPGTNGSWC EDILGGNVEH RFCNIKPCRV DGGWSRWSPW
SRCDKRCGGG RSIRTRSCSS PPPKNGGKKC AGEKNQVKPC NTKPCDDRGC PPGQEFVMCA
SQCPQRCSDL QQGIECQTNS ECQPGCRCPQ GTQLQQDGVC VQLWQCDCVD SLGQIWVAGS
THQVDCNNCT CSDGQLLCSN DSCQATCVWS SWSSWAPCSV SCGQGQRTRY RSLTPDTEGT
RCHFEEVQHR PCSPGTCPPL CLLDNQTLSV GDTWLQGECK QCTCTPEGVF CQDIDCRGAS
PYDLCPWSPW SPCSQTCGAG SVSRHRACVC EQGGDAACPP EIEAERNRVE TQLCYKQPCP
GCPMSAWSVW SQCSCASQRQ QRYRVALSSP TRGQQFCEAP FVYSSCGAPC EKQCELRGRE
DLCLGVSECT PGCYCPQGLL QYNGSCVPPE ECGCIHLQHQ APGDPPTPVT VPQGATVTIG
CSTCLCHDGS LQCDMRECEV VLSEWSGWTR CSPCVLQHNS SQMVSIQRRF RACLDLDSGL
PVSKEEESQC PGLLVEERPC PDANICRDVC QWSGWSAWTA CAEPCSGGVR QRYRQPLASP
AGPQCRSQET QTQGCNTALC PGERCEDRDR ASQDSCANKC PRSCTDLWEH VQCLQGACHP
GCRCPEGQLL QDGRCVPVTE CRCGIPSGNG TLEFLPEEEF TVDCNTCVCE HGTVVCSKLP
CPVYEPWSPW SACSASCERG RRTRTRRCQD TEGGPPCAEV MQTEICDLPS CPAGCLLSEW
SAWSECSASC DGGLSLRNKT VLREPEPGGT ACVGPLEQHV VCNTNSCLPE CPGTQVSSDC
SASCPYTCQD LWPHTQCLPG PCTPGCTCPP GQVLHRGSCV AHADCPCSPL SLPADFQSWN
VSSEYFTEAL LPPGAAIQHL YKCTLKPVLR LNVPPSYVLL VDCQWSTWSQ WSPCSASCGA
GQQSSIRLVL EPNQYGGAPC EGPNLRTTTC IAPDCACPDG EQWRRTTSEG ILLCERSCQD
IYSSSPVNCS HSAESCVCQE GLYRNPEGAC VIPALCPCHD RGVLQAGSEW EEDCLSCSCV
NGRKLCRLRC PPLSASGLLY SPLLCSVLSV SLFLSAFAQG EPVQECHRYV QVRNITKGDC
RLDNVEVSFC RGRCLSRTDV ILEEPYLQSV CECCSYRLDP NTPVRFLSLQ CESGESEPVV
LPVIHSCECT SCQGGYFEKR
//