ID A0A3P8NQ95_ASTCA Unreviewed; 796 AA.
AC A0A3P8NQ95;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Endoplasmin {ECO:0000256|ARBA:ARBA00039709};
DE AltName: Full=Heat shock protein 90 kDa beta member 1 {ECO:0000256|ARBA:ARBA00042650};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000006955.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000006955.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000006955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Sarcoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004564}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR AlphaFoldDB; A0A3P8NQ95; -.
DR STRING; 8154.ENSACLP00000006955; -.
DR Ensembl; ENSACLT00000007110.1; ENSACLP00000006955.1; ENSACLG00000004667.1.
DR GeneTree; ENSGT01020000230401; -.
DR OMA; KVSKTTW; -.
DR OrthoDB; 547579at2759; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000004667; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0035889; P:otolith tethering; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR019805; Heat_shock_protein_90_CS.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528:SF97; ENDOPLASMIN; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00298; HSP90; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..796
FT /note="Endoplasmin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018187919"
FT DOMAIN 96..255
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 291..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..318
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..796
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 91571 MW; C897D39F0733E0D3 CRC64;
MKRVWVIGLL FALLAFAAVK ADDEFDVDGT VEEDLGKSRD GSRTDDEVVQ REEEAIQLDG
LNAAQIKELR EKSEKHAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLLSL
TNEDAMATNE ELTIKIKSDK EKNMLHITDT GIGMTKEELV KNLGTIAKSG TSEFLNKMTE
MQEEEQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNQF SVIEDPRGDT
LGRGTTITLV LKEEASDYLE LETIKNLVKK YSQFINFPIY VWASKTETVE EPIDEDAEAA
EEPEKEASED EAEVEEEEED KDKPKTKKVE KTVWDWELMN DIKPIWQRPA KEVEEDEYKA
FYKTFSKDND DPMAHIHFTA EGEVTFKSIL FVPTSAPRGL FDEYGSKKND YIKLFVRRVF
ITDDFNDMMP KYLNFIKGVV DSDDLPLNVS RETLQQHKLL KVIRKKLVRK TLDMIKKIAE
EQYNDKFWKE FGTNIKLGVI EDHSNRTRLA KLLRFQTSNS ETDLASLEQY VERMKEKQDK
IYFMAGTSRK EAESSPFVEK LLKKGYEVIY LTEPVDEYCI QALPEFDGKR FQNVAKEGVK
FDESEKTKEK REALEKEFEP LTTWLKDKAL KDKIEKAVLS QRLTNSPCAL VASQYGWSGN
MERIMKAQAY QTGKDISTNY YASQKKTLEL NPKHPLVKQL LNRVNTDAED QTASDLAVVL
FETATLRSGY QLADTKAYGD RIERMLRLSL NVPLDEQIEE EPEEEPEGPA EDDSEDKEET
VDEDDDEETT KDKDEL
//