ID A0A3P8NQU5_ASTCA Unreviewed; 555 AA.
AC A0A3P8NQU5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Nischarin {ECO:0000313|Ensembl:ENSACLP00000007104.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000007104.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000007104.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000007104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8NQU5; -.
DR STRING; 8154.ENSACLP00000007104; -.
DR Ensembl; ENSACLT00000007264.1; ENSACLP00000007104.1; ENSACLG00000004780.1.
DR GeneTree; ENSGT00940000156494; -.
DR OMA; DNEKPNQ; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000004780; Expressed in body proper and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06875; PX_IRAS; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR037904; Nischarin_PX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF12799; LRR_4; 2.
DR Pfam; PF00787; PX; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..122
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 482..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 61287 MW; AF0C86FB953979E0 CRC64;
VDHSMEPVPF TEEVSERKVS VVGSELVENY TVYIIDVTDG QHRWTVKHRY SDFYDLHEKL
TAEKKVDRRL LPPKKILGKN SKSLVERRQK ELELYLQTLL QQFPQVTPTP LTNFLHFHLY
EINGITAALA EELFHKGEQL LQAGEVFSLR PLQLFSVSQQ LRMAKPTCCN GDAKTDLGHI
LDFTCRLRYL KISGTRGPVG TSNIQEASLP FDLSVFKSLL QIEITECSSQ QILGLSSLRS
SLVTMSIHRS TESMMSVLVP EASEFSQWEP EGVESGCPVT AVIPVWRNLT TLDMSHNCIS
SIDSSVKLMP KVEFLDLSYN QLSSVENLQH LYNLVHVDLS YNNLRVLEAA HTRLGNIKTL
NLAGNQLDRL TGLTKLYSLV SLDLSHNQLA QLEEIRNIGS LPCLEKLNLS SNPICIIPDY
RTKVLAQFGD RAAEVCLDCN ATTEKELDTV EVLKAIQKAK EAKDRMSGND KKVDSTRLSA
AVPPLLSSSS PSPLPASSPL PSTCSPSSVA PPAAVTSSSS SSSTSSAQQA ACPSKGNHVC
IRLCHTEGGD VCFCF
//
