ID A0A3P8NRB1_ASTCA Unreviewed; 701 AA.
AC A0A3P8NRB1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000007350.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000007350.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000007350.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A3P8NRB1; -.
DR STRING; 8154.ENSACLP00000007350; -.
DR Ensembl; ENSACLT00000007514.1; ENSACLP00000007350.1; ENSACLG00000004915.1.
DR GeneTree; ENSGT01070000253775; -.
DR OMA; WMVAFFA; -.
DR Proteomes; UP000265100; Chromosome 17.
DR Bgee; ENSACLG00000004915; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 94..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 127..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 259..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 290..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 344..363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 375..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 439..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 470..501
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 525..670
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 701 AA; 76831 MW; 61AF74AEB5E56F3C CRC64;
VEEDEDSQLI YRIERPVYNE TLIQAQLLKR KEDTTTNCQK LAEKFQCSSE KAKAAALSFM
PILSWLPSYP VKKYLFSDVV SGLSTGVVQL PQGLAYAMLA AVPPVYGLYS SFYPVLLYTF
FGTSRHISVG TFAVISLMIG GVAVREAPDS MFMNINATGS NASDAINVEL RDKSRVQVAV
MVTTHPGQPP IVLGLLRFGF VAIYLTEPLV RGFTTAASMH VVISQLKYLL GVETQRYSGF
LSAIYSVKAV LSRITSTNIA TFLLGLGCII FLYVIKILNE RFKKKLPIPI PGEIIVVIVS
TGISYGLSLS KEYKVHVVGN IPTGLRPPAA PNISLLPNLV TDSFAIAIVG FSMDVLLAKI
FALKHGYSVD GNQELIALGL CNFISSFFQT FAVTCSMSRS LVQESTGGKT QIAGLLASLL
VLVVVVAVGF VFEPLPQTAL AAIIMVNLIG MFKQFRDIPS LWRTSKIELA IWVIAFIASV
LLGLDYGLLV AVTFAILTVI YRTQSPKTSI LGHVANTGLY CDVDEYEEAA EYEGIKIFHS
NSSIYFANSD LYVNSLKEKT GLNPEHLQAA RKAQKKKERR RRTDEAVTHD VLSQSHVAED
QKNGQFGDRH GDSEEAVFLE PFSTVHSIIL DWTSATFIDS VGAKAIRQII KEHAAIDVRV
VIAGCNSKGV CFPCGLNHTT YIIFPVVHNC VKNSLNNMML F
//