ID A0A3P8NTD5_ASTCA Unreviewed; 1033 AA.
AC A0A3P8NTD5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=SLIT-ROBO Rho GTPase-activating protein 1-like {ECO:0000313|Ensembl:ENSACLP00000008032.1};
GN Name=SRGAP1 {ECO:0000313|Ensembl:ENSACLP00000008032.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000008032.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000008032.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000008032.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8NTD5; -.
DR Ensembl; ENSACLT00000008218.1; ENSACLP00000008032.1; ENSACLG00000005406.1.
DR GeneTree; ENSGT00950000182824; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000005406; Expressed in camera-type eye and 8 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 21..309
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 472..663
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 712..771
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 772..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 118102 MW; FFA31E2AD60FB9AB CRC64;
FSSITRSQKA KTSVYEYQPH ICIRAQLVEQ QKCLDQQTEM RVQLLQDLQD FFRKKAEIEM
EYSRNLEKLA ERFMAKTRST KDHQKDQNLL SPVNCWYLLL NQVRRESKDH ATLSDIYLNN
VIMRFMQISE DSTRLLKKSK EIAFQLQEDL MKVLNELYTV MKTYHMYHSE SISAESKLKE
AEKQEEKQIG RADPVFSIRM EEKYQRRSSV KKIEKMKEKR QAKYSENKLK SIKARNEYLL
TLEATNSSVY KYYIHDLSDL IDCCDLGYHA SLNRALRTYL SAEYNLETSR HEGLDIIENA
VDSLDPRSDR QRFMEMYPTA FCPPAKFEFQ PHMGDEVCQI SVQPPVNGEL ILRFQQLQSR
IATLKIENEE IKKTSEATLT TIQDMVTIED YDVSECFHHS RSTESVKSTV SETYLSKPSI
AKRRANQQET EQFYFMKFRE FLEGSNLISK LQAKHDLLKR ALGEGTFTTL YLPLDSSLYC
TCDSGQAIPR VVESCIRYIN LYGLQHQGIF RVPGSQLEVN DIKNSFERGN DPLADDENNH
DINSVAGVLK LYFRGLENPL FPKERFNELL SCIRIENLYE RALYIRKILL TIPRSVLIVM
RYLFAFLDHL SQYSDENMMD PYNLAICFGP TLMPTPDSQD QVSCQAHVNE IIKTIIIHHE
TIFPDVKELD GPIYEKCMAG GDYCESPYSE HGALEEVDNE GGTETHTSED EGEPIEAIAK
FDYVGRSSRE LSFKKGASLL LYQRASEDWW EGRHNGIDGL VPHQYIVVQD IHRKRSDPPS
RRPPARPSDV HCMVHTSQQS HSGHGGTPEM GSPVLGHFSP RDMLRSRNHV AIDSPERRRR
AGHSSLTNIS RHESLKKMES PPIRRSTSSG QYTGFTDAHH HHHHHHGGKP LDPETIAQDI
EETMNTALNE LRELERQSSA KHAPDVVLDT LEQRQTSGSS GGGPTPASSS ESLSPIHAVM
LRSTANTEPP TRRSTSSSND SVSTFKPVVA PRMGVQLKPP ALRPKPMVLP KSNQAPQPPA
NSSQDPLDKS CTM
//
