ID A0A3P8NVX1_ASTCA Unreviewed; 534 AA.
AC A0A3P8NVX1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Heat shock transcription factor 1 {ECO:0000313|Ensembl:ENSACLP00000008864.1};
GN Name=HSF1 {ECO:0000313|Ensembl:ENSACLP00000008864.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000008864.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000008864.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000008864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC ECO:0000256|RuleBase:RU004020}.
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DR AlphaFoldDB; A0A3P8NVX1; -.
DR Ensembl; ENSACLT00000009069.1; ENSACLP00000008864.1; ENSACLG00000006001.1.
DR GeneTree; ENSGT00940000158421; -.
DR OrthoDB; 1117127at2759; -.
DR Proteomes; UP000265100; Chromosome 22.
DR Bgee; ENSACLG00000006001; Expressed in camera-type eye and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR010542; Vert_HSTF_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF274; HEAT SHOCK FACTOR PROTEIN 1; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR Pfam; PF06546; Vert_HS_TF; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 58..82
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS00434"
FT REGION 262..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 58193 MW; E015205D6B445138 CRC64;
MEYPGGGGAV LSSGNVPAFL TKLWTLVEDP DTDPLICWSP SGTSFHVFDQ GRFSKEVLPK
FFKHNNMASF IRQLNMYGFR KVVHIEQGGL VKPERDDTEF QHPFFIRGQE HLLENIKRKV
TNVSSVRQDD AKISAEEVNK ILNDVQLMKG KQETIDSRIV TMKHENEALW REVASLRQKH
TQQQKVVNKL IQFLVSLIQS NRLLGVKRKI PLMLNDSGNT HSMPKYSRPF SLEQAAANLF
SADTSVTSGP IISDITDMAT SGSDELASDW TDQGESQSVD IKEEPSSPEV EVCPVLEEVA
APVDTPFSPT TFINSILEEN EPPTPVTSTS SAPTAASPIV VMSPVSTGPL SSASSTQSLT
SVTTANTAPS TTAPQKKCQA IACIDRPRPI PSAGGLPPDV WRFLSAQPDK SELLDHVDTI
DSGLENLQNI LNTQTFSLDT VPFIEFFSSS GSPADFDLDS LDNLLSDEAP KGSEESGTGK
QLVQYTPVQT SESDSGADLP ALLELETEPF LSSDPHTEDP GITLLNHGNL DSNL
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