ID A0A3P8NX06_ASTCA Unreviewed; 716 AA.
AC A0A3P8NX06;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=ADP-ribosylation factor-binding protein GGA3-like {ECO:0000313|Ensembl:ENSACLP00000009259.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000009259.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000009259.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000009259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR AlphaFoldDB; A0A3P8NX06; -.
DR Ensembl; ENSACLT00000009476.1; ENSACLP00000009259.1; ENSACLG00000006297.1.
DR GeneTree; ENSGT00940000157333; -.
DR Proteomes; UP000265100; Chromosome 6.
DR Bgee; ENSACLG00000006297; Expressed in ovary and 7 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF3; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 15..145
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 170..297
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 587..708
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 296..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 77680 MW; BC37FE346EFAB95B CRC64;
MADYGESLES WLNKATNPSN RQEDWEYIMM FCDQINKELE GPQISVRLLA YKIQSPQEWE
AMQALTVLEA CMKNCGRRFH NEVGKFKFLN ELIKVVSPKY LGDKVSEQVK KKVIEMLYSW
TVSLPDETKI AEAYQMLKLQ GIVLADPEIP LDATLIPSPS PRPKNPVFED EKKSKRLSEL
LKSKKPEDLQ EANRLIKNMV KEDEVRTQKA TKQKSTLEAV NNSVKLLNEM LAHFNPEDST
DADRELIREL YGDCDKLRQT VVQLATETED NDSSLGTGST NQSEILIDLV GLDIQSSSAS
EQQPPASSQS FPADLLCGSA ATDPPSQSVN VPSTALSLLD EELLSLGLNE PITELNKSTH
GNPSNPLPST QDSSQDLDLF DTLPTVPVFS TPSLFLDALS TTGAPANPSK TYTPASSLNF
TGPVFSTPLA STTSLSTTPI STTSLSTTSV ISPQPFSSIL TTVAPAAPPQ SFSLTSSAPS
AADITPQLIS TSTLGFHSPS LSPGQILQDL TLLDLGNNNS LEATSTQIIS EGIHAWSAPL
SIKSQADDSP LLRSLSPVLP LSQSSPGRGQ EVSLANVFVP LDTIKPSKVC PVTAYDKNGV
RVLLHFATDF PPGRPDVLVM VASMLNTATQ PVKNIVLQAA VPRTMKVKLQ PPSGTELASF
NPILPPAAIT QIMLLANPLK EKVRMRYKLG FTLGDQPFTE VGEVNDFPPV DKWGAL
//
