ID A0A3P8NXH3_ASTCA Unreviewed; 682 AA.
AC A0A3P8NXH3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000009434.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000009434.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000009434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR STRING; 8154.ENSACLP00000009410; -.
DR Ensembl; ENSACLT00000009632.1; ENSACLP00000009410.1; ENSACLG00000006402.1.
DR Ensembl; ENSACLT00000009654.1; ENSACLP00000009434.1; ENSACLG00000006402.1.
DR GeneTree; ENSGT01080000257336; -.
DR OMA; LYLRIVK; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000265100; Chromosome 17.
DR Bgee; ENSACLG00000006402; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF162; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 197..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 245..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 329..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 366..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 396..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 614..636
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 19..644
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 445..500
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 682 AA; 74925 MW; 57DBB5D7E12D2941 CRC64;
MSVESKKTRE ACCSKLKLFL ASLAFVYFAK AFAGAYMKSS ITQIERRFDI PSSLIGVIDG
SFEMGNLLII AFVSYFGAKL HRPRLIGIGC LIMAVGSFLV ALPHFFQGLY KYETSVSHKA
AVNSTETILP CLSNHSMTDA DDTLDAETKL ECEKAAGSPM WIYVFLGNML RGIGETPVMP
LGISYLDDFS REENTPFYLA CIHTVGILGP MFGFMLGSFL SKIYVDTGFV NLDTITITYK
DSRWVGAWWL GFIVTGTVVL LSSIPFFFLP KSLPKQGQEQ EEIQSKSTEL ATKTEQEQFL
PEETQEKVKF QEMAKDFIPS LKRLFRNRIY SLIILASLVI VNGFIGLITF KPKYIEQVYG
QSATKAIFLI GILNLPAVAL GFITGGFLLK RFKLGIVGAA RVAISASLGS FCLLAVQIFV
QCENAEVAGL SMSYQRVPQV SYNPQTLLSQ CNGHCFCSVK HWDPVCAYNG MTYASPCLAG
CQTSTGMGKE MVFHNCTCIN EAGLAANASA VLGQCPRKDD CDIKFKIYMA LSVIGSYISA
CGGTPGYIVL LRSIQPDLKS LALGMQTLIV RTLGGIPPPI YFGALIDRTC LKWGTKHCGG
RGACRLYNAN AFRLTYLGMI TGLYFLANTV WGYLYYSIVK RQKKIALKNQ SKENGQESNA
VTNGHANINI ADIDDMGTEC TI
//
