ID A0A3P8NYL7_ASTCA Unreviewed; 602 AA.
AC A0A3P8NYL7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Basic helix-loop-helix ARNT-like protein 1 {ECO:0000256|ARBA:ARBA00041169};
DE AltName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 1 {ECO:0000256|ARBA:ARBA00042144};
DE AltName: Full=Brain and muscle ARNT-like 1 {ECO:0000256|ARBA:ARBA00041751};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000009867.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000009867.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000009867.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
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DR AlphaFoldDB; A0A3P8NYL7; -.
DR Ensembl; ENSACLT00000010093.1; ENSACLP00000009867.1; ENSACLG00000006711.1.
DR GeneTree; ENSGT00940000157523; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000006711; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11438; bHLH-PAS_ARNTL_PASD3; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23042:SF52; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 55..108
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 126..191
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 330..379
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66486 MW; 64E8D95513B51B38 CRC64;
MADQRMDISS TMTDFMSPSS TDLISSSIST PGMDYTRKRK GSTTDYHDQQ GRIKNAREAH
SQIEKRRRDK MNSFIDELAS LVPTCNAMSR KLDKLTVLRM AVQHMKTLRG AANPYTEANY
KPSFLSDDEL KHLILRAADG FLFVVGCDRG KILFVSESVY KILNYSQNDL IGQSLFDYLH
PKDIAKVKEQ LSSSDTAPRE RLIDAKTGLP VKTDITPGPS RLCSGARRSF FCRMKCNRQS
VKVEDKDFPS TCSKKKADRK SFCTIHSTGY LKSWPPTKMG LDEDNEPDNE GCNLSCLVAI
GRLHPHIVPQ PSLADIRVKP TEYVSRHAID GKFVFVDQRA TAILAYLPQE LLGTSFYEYF
HQDDISHLAE CHRQVLQMRE KINTNCYKFK IKDGSFITLR SRWFSFMNPW TKEVEYIVST
NTVVSCPMME GSDYPQSAAS PQSMDSVLTS EGGGRRALQT VPGIPGGTRA GAGKIGRMIA
EEVMEIQRIR GSSPSSCGSS PLNITSTPPP DTCSPGGKKI QNGGTPELQS TGMLPGPDSV
GYPYSNQSIM SDNSHLSIDI MDEPGSSSPS NDEAAMAVIM SLLEADAGLG GPVDFSDLPW
PL
//
