ID   A0A3P8P0Y3_ASTCA        Unreviewed;       410 AA.
AC   A0A3P8P0Y3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Alpha-1-antitrypsin homolog {ECO:0000313|Ensembl:ENSACLP00000010649.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000010649.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000010649.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000010649.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   AlphaFoldDB; A0A3P8P0Y3; -.
DR   Ensembl; ENSACLT00000010900.1; ENSACLP00000010649.1; ENSACLG00000007284.1.
DR   GeneTree; ENSGT00940000160877; -.
DR   OrthoDB; 3218836at2759; -.
DR   Proteomes; UP000265100; Chromosome 15.
DR   Bgee; ENSACLG00000007284; Expressed in liver.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF363; SERINE (OR CYSTEINE) PROTEINASE INHIBITOR, CLADE A (ALPHA-1 ANTIPROTEINASE, ANTITRYPSIN), MEMBER 1, LIKE PRECURSOR-RELATED; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..410
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018183630"
FT   DOMAIN          52..407
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
SQ   SEQUENCE   410 AA;  46108 MW;  FD15512E5742E6A1 CRC64;
     MLMTLKMHFC SCALIALLLA VASADHHLHH NRGSEDHMSC HKLSAPNADF AFALYKRLNA
     RTAAGNNIFF SPLGISTALS VLSTGAHSET HSQLFSSLGY STLNQTQVNE AYQHLFHVLG
     QSQENQKLDV GNTIAVHSGF SPLEKFLNDV KQHYSGEVLQ INFTNPAEAA DKINRHIANK
     TQDKIKDMVN DVDPETMMML INYVYFKGYW KKPFNSEMTH KADFHVDSRT KVQVDMMVRT
     GYYHIFEDRA NHTSIILLPY ESQTSMMIVL PDEGWMRSVE ENINKDHIRN WQNSASMMYV
     ELYMPKFSIA TNASLRNILQ EMGITSAFEN TADFSAVSNK FPLKVSKASH KATISVTEMG
     TEAAAITISE WILLTTPTPV RIDRPFLVFI VENSTGSILF MGRINKPTAS
//