ID A0A3P8P1I4_ASTCA Unreviewed; 1706 AA.
AC A0A3P8P1I4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Fer-1 like family member 6 {ECO:0000313|Ensembl:ENSACLP00000010849.1};
GN Name=FER1L6 {ECO:0000313|Ensembl:ENSACLP00000010849.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000010849.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000010849.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000010849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8154.ENSACLP00000010849; -.
DR Ensembl; ENSACLT00000011113.1; ENSACLP00000010849.1; ENSACLG00000007330.1.
DR GeneTree; ENSGT00940000159069; -.
DR OMA; SPNEDMM; -.
DR Proteomes; UP000265100; Chromosome 16.
DR Bgee; ENSACLG00000007330; Expressed in anal fin and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF37; FER-1-LIKE 6 (C. ELEGANS); 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1674..1695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..107
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 145..279
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 733..860
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 889..1013
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1192..1311
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1432..1581
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 350..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1062
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1626..1645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1706 AA; 191392 MW; 9E00EA392F27DD7C CRC64;
AKPQSFQIAI NITEARQLVG ENIDPSIVIE IGDEKKQTSV KEGTNAPFYN EYFVFDFFAL
KDVFFDKVIK LTVLHSKMLR SFSVGSFKLD VWTVYKQPGH QFINKWAMLT EGGDISTGVK
GYIKCDISLS SKGDTMQPGQ KASDAEEQID KNLLIPEGFP SERPWARFCV KVYRAEGLPR
NNSSIMANVT KAFIGENTAL IDPYVVVSFF KQVGRTSTQK STADPVWNEQ IVFTEMFPPL
CQRLKIQVWD EGSMNDVAIG THYFDLRCIS NEQDGDRGFL PTFGPAWINL YGSARNFSLG
DDTGELNEGI GEGVSYRGRL YMELAVEILS GGTGSDSKLS RIMKPIKDAK AGKAGGKDGK
TPAGGAGTGG AADDDKGRAA AEVLPVDPPP LNADDNESFL LFGALFEATM IDRKIGDRPI
SFEFSLGKWM CGVVLDFPDT SDVFGSFSLS TSPNSPTSPL LPRETQDAAM TSKSTTSPEK
PIIVEGNRYY MYLPLEKQKP CINVLSHWEE RTYRMHNSNM LDNIAVLLEE GVTNAWELHR
KSDPAAELLM KSVLQDFCAD ARSFIEAAEA KLKAELKSTY LTQLDKKRLT MCKQELESMI
GEAQSLVGRK KNAGGVKEML QDAAKLTHKL RFLVEEPQHT VPDMFVWLLS NNKRVAYARV
RTRDLLYSSR QEARGINCGK VITLFLKPPG KRVAGLSVQA KLDVYLWFGA CRDSSHMLDN
LPAGFTPATG GADANSPPTH LHCEGETEHQ FQLRCHMYQA RGLIAADNTG LSDPFARVTF
LSHSQTTNII SQTLSPTWNQ CLPMSHLLLS GDLQYIQREP PHILIEVYDD DALGKAEYLG
ATVAVPEVCL SSAPYTPPTL QYNALHCGSQ PGGELLAAFE LLQVNLEEQD GGIYTVPAYI
RPVLSTYRLE VLFWGLRELK KVQLLSVDRP QVIIECAGKT LRSSVIQKYK SNPNFTTLVD
AIELELPENE HLHPPLSITV VDWRAFGRST LVGNHIINNL KAFKPIPLPA LPAPIQTHKP
PKDISTPGPA MTVEPHSAED FRITVEDEPL PPAPPPAPPI PKQEESKAKS TRSRSTKRRK
RTIADESAES VIDWWSKYYA SVEREVSKIA GLLSKKIKQL FNLILALQLY NKELESEFGS
FDDWVKTYEL FRGKASEEEG SNEERFVGKF KGRFCLYKLA EEEEEDWHEA IDAGSFRVNR
GIPPNSSVQV LIRVYIVCAS NLHPADPDGK ADPYIVLRLG KNEIKDRDNY IPKQLNPVFG
RSFEMQATLP QESLLSVFIY DHDLVGGDDL IGETRIDLEN RYYSKHRGTC GLPAEYSLEG
YNAWRDCLKP SELLAKMCRE SGLDSPHFSP GRIIVSEKVF TGKTLFMHED EPVESYEHLS
LKILHRWAEI PGVGCTLVPE HIETRTLFNK ARPGMDQGQV QMWVDMFPMD LPHPGPPVDI
SPRKPKGYEL RIIIWNTEDV ILEDSHFLTG QQFSDIYIKG WLKGLEDDRQ ETDVHYNSLT
GEGNFNWRFV FPFSYLPAEK VVVVRKRESI FSLDKTEQKI PAILILQVWD FETLSSDDFL
GTLELDLHGF TRGAKTAKLC KADMLTDGTE RISIFQQKRA RGWWPFTKSG ELTGKVEAEF
HLVTAEESEK NPVGRARKEP EPLPKPNRPD TSFSWFVNPF KCFFHLVWRS YKKYIIIGII
LLITALFLAL LFYTLPGAIS NKIISG
//
