ID A0A3P8P2C5_ASTCA Unreviewed; 1078 AA.
AC A0A3P8P2C5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000011172.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000011172.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000011172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3P8P2C5; -.
DR STRING; 8154.ENSACLP00000011172; -.
DR Ensembl; ENSACLT00000011452.1; ENSACLP00000011172.1; ENSACLG00000007628.1.
DR GeneTree; ENSGT00940000154838; -.
DR Proteomes; UP000265100; Chromosome 3.
DR Bgee; ENSACLG00000007628; Expressed in spleen and 6 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 3.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1026..1045
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 91..272
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 381..441
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 447..503
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 507..568
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1078 AA; 118627 MW; F08D4E69FE194083 CRC64;
MIMLNAALGF NIDPVAWKTL SNSAAGFVTK NTQPAELWHL GFVSSQVCGP TIPKDCRSIT
MYNGVCFQME SFKRIRPPIP SSIQECRTQA DIAFLLDGSG SVDNTDFQTM KKFVKDLIQS
SLSSDTQFSV SQFSTSPEVH FYFKKFSSSG SVETDINDIS QQEGATYTAE AIRYVVNNVF
TPQRGSRQNV KKVLIIITDG QSHDRTDLGG AAQLAESKNI VRFAIGVGNA FANPDAKREL
RTIASSPSNK HVFQVENFDA LEVIRQNLQD KIFSIEGSQS SGESLKMEMS QEGFSAVYVP
EGIQTSIVGA NQWRGGYVQY TTGGQKVKTY EDVSLEPDSY LGYSMAIAKS WHGSLTVVGA
PRYKHRGVVF AVNRENLKNQ KIEPFSSQYQ TGAYFGAEVC TMDINNDDIT DLIFISAPMY
MEPDREGRVY VCRLTGLIVE CNFEDPLILR GHAAVKGRFG SSLAVLPDLN SDGFMDLAVG
APLENNGEGS VYIFHSEGGR ISPTYSQRIT GSEVQSGLKF FGVSISQSSF DQSGDELPDL
AVGSKGRVAL LRSRPIVMVR AEVSFSPNKI PTQNVDCSKP LENTAEICFT MSRVSTVGTA
RARIDYTITL DATRKPPNNR AYISGKQREQ SGSVTVDLGI KKCSPVKFLI EACPKDALNQ
LSNELKFTFD GSASNTNLRP SLAPQAQTTT IHPLGFEINC GTDNKCVDNL KVDFNFTRSS
EVKVGIEELL NVTVTVENRG ENSYNSRVIL TYPAGLSYRK FTIQQGRIEC NSLDSEDGLS
QGRTDCTIDK PIFKSKTGAS LIVSYGIEPN SQLERKIFVT ANATSGNQEH ASTSELYKKK
SIDVKYSIFM TFESPLSYNN FTFGKNDLKK PVQKSVKVTN DIRALNFTVV IRVPVRLGEK
DIWVDLSSLQ IPDCQKGDEE EPSVRDFVRK IQKDKVVDCS VATCRVFKCN TFLERLQSTT
YKISANISSR WIQQIGLQSA KFLLTSTASL DYDKTQYIYF STGSDNSPPI EAEVEVYPEP
DFTKEIVGGC LGGLAFLALL TAGLYKAGFF KSKYKQMINE NAADGPSPGT DAGATLPE
//
