ID A0A3P8P2L4_ASTCA Unreviewed; 1321 AA.
AC A0A3P8P2L4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 3 {ECO:0000313|Ensembl:ENSACLP00000011248.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000011248.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000011248.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000011248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSACLT00000011528.1; ENSACLP00000011248.1; ENSACLG00000007535.1.
DR GeneTree; ENSGT00940000153496; -.
DR Proteomes; UP000265100; Chromosome 4.
DR Bgee; ENSACLG00000007535; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 8..96
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 494..565
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 179..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..163
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 179..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 146730 MW; E892C497593F3E2F CRC64;
MMELQIDEVV YQDDYGSGSV MSERVSGLAN SIYREFERLI HSYDEEVVKE LMPLVVNVLE
NLDAVLTENQ EHEVELELLK EDNEQLITQY EREKALRKQA EEKFIEFEDS LEAEKKDLQI
QVEFLELQGK QLELKAKNYS DQITRLEERE SDMKKEYNAL HQRHTEMIQT YVEHIERSKM
QQAGSNSQSE GTGCGRSQRH TWRKSSKAER PPSLSLYPDG MVRGGLGGAR MIPGKDIWQE
DGSESDSVAA TPSSTGSKSN TPTSSVPSAT VTPINESFHG HDFDVTRPGN RRKSAKRLSR
NMEVQVSQET RNVSIGMGSS DEWSEFQELI DSTPELDMCL DPRIYGGGNS PSQGIVNEAF
GINTDSLYHE IKDAKSDIIG DVDAGAELLG MSKEWENMLA ENKQLLQTKN ALNIVKNDLI
AKVDELSGER EVLREELEAV RQSKNKVDAR IKELEEELKR LRAEALGASR DSKDEVGDDF
SSPMQDGDMT MTQRRRFTRM EMARVLMERN QYKERLMELQ EAVRWTEMIR ASRENPPIQE
KKKSTIWQFF ARLFSSSSSP PPVKRPFCNV NIHYKSPSPA GFPQRRSHTM CQISTSNRTL
EFFPEELASN GVASLLSDSA MLARREQRRE QYRQVREHVR RDDGIMQTCG WSVPSRFKQT
GGQTDSAQDS PLKRQQTTNE KEDNRMKNVP VPVYCRPLVE KDPNRKLWCA AGVDLTGWRV
SSQETSEKAP ACSTDPLHAE EDGADKKKNH TSPEKRKSKE LQETDTMSSR VWILTSTHSA
SKVVIIDANQ PGSLVDQFNV CNAHVLCISS VPAASENDYP AGEIVLDPGE GGAGGGEDTG
SVEGMLAGIT LVGCATNCSV ARSNCSSRTD TPIMDKGQAP IAPPMNGKIH PAQSAEEATE
ATEVPESTAS NTEMRSGPPG PFTEHVFTDP QPRPADASDR SSGQSKEETS HPPESEDGGD
ETKNYTSVAP TMWLGAQNGW LYVHSAVGNW KKCLHSIKLK DSVLSLVHVK GRVLVALADG
TLAIFHRSED GQWDLSNYHL MDLGRPHHSI RCMAVVHDKV WCGYKNKIHV IQPKSMQIEK
SFDAHPRRES QVRQLAWIGD GVWVSIRLDS TLRLYHAHTH QHLQDVDIEP YVSKMLGTGK
LGFSFVRITA LLIGGNRLWV GTGNGVIISI PLTETNKVSP TSSGGVIHVY GDDGSEKSSG
SFIPYCSMAQ AQLCFHGHRD AVKFFVSVPG NVLATLNGSV LDSPSEGQGS TAPTETEAQS
VQNVLVLSGG EGYIDFRIGD GEDDETEEGE NGGGGASQNK PTLCKAERSH IIVWQVSYVP
E
//
