ID A0A3P8P4C0_ASTCA Unreviewed; 547 AA.
AC A0A3P8P4C0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Occludin-like {ECO:0000313|Ensembl:ENSACLP00000011866.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000011866.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000011866.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000011866.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR AlphaFoldDB; A0A3P8P4C0; -.
DR Ensembl; ENSACLT00000012158.1; ENSACLP00000011866.1; ENSACLG00000008124.1.
DR GeneTree; ENSGT00940000167296; -.
DR OrthoDB; 5360956at2759; -.
DR Proteomes; UP000265100; Chromosome 18.
DR Bgee; ENSACLG00000008124; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 6.10.140.340; -; 1.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288:SF38; OCCLUDIN; 1.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..277
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 439..547
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 475..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61534 MW; F51EF4D15DD48015 CRC64;
MYEPRYYDSP PVYSPPYSTT SHSLYPPRSV QSPRSQNAPY TYDVPPESYY MEGKPQHFYR
WFSPPGFVKT FQGATVLMCF LIFALVASTL VWDMNRFGYG GYGVVDAGSV GGLGSGYYGG
SYGYGGSYMT PQSAKAAMIS MGAINFLVSL GFLVASFSRS RSIRTCRFYL TVFICDIILA
VLQGIIDIIF VIGVNPMSQS SQSMLYNPML MMCQNIQGSP SLSGSVGAGF PGGFPLFNQY
LQHYCYMDPE EAVAFVLGLL VVVALSFSAY FAYKTRSKIW RHGKANIHWD EAVARPSEGQ
DIQDWVNHVG EVRSTQQAPT VVVSERAAPD LRAENSAVSY GNGAVSIHSE GNYKTNSFSA
NKSKTHGAEP LYQNCRAKVC PSSSSDESDS IRSPPYYVKK ERKKDREPMP AAQVMIESQY
ETGYTTGDTG NGLDRDHTDY LYRLYPEITS DEQRRRYKKD FDSDLSRYKI LCSELDDISD
KMHKLSRELD ALEEDSMKYQ GVADEYNQLK CLKSTPEYQA KKKQSKELRQ KLFHIKRLVK
IYDQGFC
//
