ID A0A3P8P589_ASTCA Unreviewed; 369 AA.
AC A0A3P8P589;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=SEPTIN5 {ECO:0000313|Ensembl:ENSACLP00000012149.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012149.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000012149.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000012149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR AlphaFoldDB; A0A3P8P589; -.
DR STRING; 8154.ENSACLP00000012149; -.
DR Ensembl; ENSACLT00000012448.1; ENSACLP00000012149.1; ENSACLG00000008299.1.
DR GeneTree; ENSGT00940000159913; -.
DR OMA; RALCIQT; -.
DR OrthoDB; 5396944at2759; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000008299; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF68; SEPTIN-5; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR006698-
KW 2}; Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR006698-2}.
FT DOMAIN 39..312
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT COILED 339..366
FT /evidence="ECO:0000256|SAM:Coils"
FT SITE 161
FT /note="Important for dimerization"
FT /evidence="ECO:0000256|PIRSR:PIRSR006698-2"
SQ SEQUENCE 369 AA; 42714 MW; 16F5E7056BBDAE94 CRC64;
MTADSRYKSR APQTDDGEEK EYVGFATLPN QLHRKSVKKG FDFTLLVAGE SGLGKSTLVN
SLFLTDLHKD RKLLNAEERI SQTVEITKHT VDIEEKGVKL KLTVVDTPGF GDAVNNTACW
RPITDYIDQQ FEQYFRDESG LNRKNIQDNR VHCCLYFIPP FGHGLHPVDI EFMKALQDKV
NVVPLIAKAD CLTPFEIKKL KERVREEIDK YGIKIYQFPH CDSDEDEEFK QQDKELKEST
PFAVIGSNTV VEARGHRVRG RVYPWGIVEV ENPSHCDFVK LRTMLIRTHM HDLKDITSDC
HYENYRAQCI QNMTSKMNAD KRVESPNPIL PLSTPDIEAE KLIKTKDEEL RRMQQMLQKM
QQQMHEQEL
//
