ID   A0A3P8P5B9_ASTCA        Unreviewed;       978 AA.
AC   A0A3P8P5B9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Elastin microfibril interfacer 1a {ECO:0000313|Ensembl:ENSACLP00000012212.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012212.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000012212.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000012212.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; A0A3P8P5B9; -.
DR   Ensembl; ENSACLT00000012512.1; ENSACLP00000012212.1; ENSACLG00000008275.1.
DR   GeneTree; ENSGT01030000234633; -.
DR   Proteomes; UP000265100; Chromosome 15.
DR   Bgee; ENSACLG00000008275; Expressed in spleen and 3 other cell types or tissues.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   PANTHER; PTHR15427:SF1; EMILIN-1; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF07546; EMI; 1.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
DR   PROSITE; PS51041; EMI; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          32..106
FT                   /note="EMI"
FT                   /evidence="ECO:0000259|PROSITE:PS51041"
FT   DOMAIN          834..978
FT                   /note="C1q"
FT                   /evidence="ECO:0000259|PROSITE:PS50871"
SQ   SEQUENCE   978 AA;  109299 MW;  60DA4E958B8B2FD3 CRC64;
     GWMDEVDVSD LRPWHMLWHR DQVDGVFANV LTQNWCAYVV TRTVSCVMED GVETYIKPDY
     QRCAWGQCPR VAYRTYRRPR YKVAYKMVTE MEWRCCHGYS GEDCHSGPQG TPETGVADTD
     TEKIRQLENT IHGLTKDLSN MQTTINGINQ RHGLTGAIVP ADSAQPHMKE TINSIQTKLD
     HLYNRTQAHD QTLLTINNHL VNGGGNELDG ADRGGGGGDQ LNILKEEILT ELERRVSLSC
     SSCQVGVEDM RRQQQQDRDR IAALEKRISS IDQHLRQSLE ISRSETERSQ ACCNTVTELG
     RRLSDVEVRL TSTANKCDAI KGRLDKELGT GGGKGRVTED RLNGRLRELE KRMNTTMRKT
     EQRCTNTGNN MKETVQRDVT QLRNSVLVQL DDHSYKIGKV ELDVAVLADT VKDHSRRLSK
     LENITTFLDR RLTSTTDMCR DTCGPNARDR TSDETVKTLE WRVVANQDEI QKFNTKLNNL
     SVSGDSLLER VINLTTDVKK ITAVTGKDGE NFNRIFTEVE TLGRDFKECL ICSTVEKDLL
     TFKNSTTISL NRCQTALTDL RRKVDSGESV CSQVCSNLQE EVGRLREDVE ECTVQCKTNI
     NDLKKRLEGH TVHSGKLGGD LKSIQGELAE VMDTFSSIND TLKGLGRTVQ THGHTITDLT
     HIKDNIIVEV RICDADNSLV MHTSIQIIRS NHVTEIGECR RSSDGLDRRL SNLEKVSGRF
     DSVSGKLEGI KEGLDRHVSG LWTSVNGLNV TVTSQGNAIE NIQNVQLPHI HSNIHRLNSS
     VVDLVRDFHR FKTRDFKGES QRADGVGFEC WSRDSCSQLK GGLRGEQGPP GSDAHVPRLS
     FSAAMTRPMR NTGTIVFNEV FVNENNAYNP KTGYFTAPVR GKYFFSGILT GHKNIKIEAV
     LSKSNTGVAR ADSAGYQPEG LEKPMAEAKH IPGALAVFNI ILPMEEGDTV CIDLVTGKLA
     YSSEPLTIFS GMLLYETI
//