ID A0A3P8P5D7_ASTCA Unreviewed; 1190 AA.
AC A0A3P8P5D7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Protocadherin-1-like {ECO:0000313|Ensembl:ENSACLP00000012199.1};
GN Name=PCDH1 {ECO:0000313|Ensembl:ENSACLP00000012199.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012199.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000012199.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000012199.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8P5D7; -.
DR STRING; 8154.ENSACLP00000012199; -.
DR Ensembl; ENSACLT00000012499.1; ENSACLP00000012199.1; ENSACLG00000008333.1.
DR GeneTree; ENSGT00940000155521; -.
DR OMA; TNECSEL; -.
DR Proteomes; UP000265100; Chromosome 10.
DR Bgee; ENSACLG00000008333; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013585; Protocadherin.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF247; PROTOCADHERIN-1; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1190
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018006688"
FT TRANSMEM 817..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 133..244
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 245..351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 360..470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 471..576
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 577..679
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 700..799
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 848..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 129553 MW; B70100FD66562A0E CRC64;
MELNLQVILC WVVVLHCGSA EGSILYRVQE EQPPNTLIGS LAADQGLPDS GHLYKLEVGA
PYLRVDGKTG DIYTTEIPID RETLRDCRSL AKGKPCYLEF EVSVTDLIQN QSPRLIEGRI
EVQDINDNTP QFPSSVLTIS VPENTIMGAL FSIPLATDRD SDRNGVADYA LTAGPDAATL
FGLQVADDRG GKLPQLIVLG NLDRELKDSY DLTIKAVDGG NPQRYSSALL RVVVTDANDN
APKFEKSTYE AEVSENSPVG HSVLQVKAND SDMGPNGEIE YTLHQAVDPV PKLLRIDRST
GIIYVKGPLD REEISSLSFY VIARDKGPQP KSSKTFVTIE VTDQNDNAPA VEIRGIGLVT
HSEGVANISE DMPVGTAVAL VQVSDKDEGE NAVVTCVVAG DVPFQLRPAS DSTSDNKRKY
FLQTTTPLDY ERVRDYRVEI VAVDSGNPAL SSTNSLKVQV TDVNDNSPIF SPTLFEVDFA
EENQPGEKIL DVIATDADSG TNAELLYNIL PDSSIKGLFE IDPNTGEVRA KSSLDREHKE
QYEFRVTAAD KGSPVHKGTA TVVIKVIDRN DNDPKFMLSG YSFSVLENMP PLSPVGMVTV
LDMDKGENAH VHLSVEPDEG KFVVQNGTGT ILSSISFDRE KESSYNFRLK AVDGGEPPRS
SYVGVTINVL DENDNDPVIT KPSNSSFRRL SPLASPDSHV EVVEAEDLDN GPNAELVFSI
AGGNPYQLFR ISPSSGEITL AKEMTRKHGG LHRLVVRVSD KGKPARHATA LVHIYVNETI
SNVSLVEALV GHSLYTPLDR DIAGDPDNGF AAQRSNILFG SLAGVAGVVM LILVVVFIRH
RIQRETKSGY QAGKKETKDL YAPKQAPKNT KGKRGRKGKP QKSPKPLGED EEVSLQKSLK
FNLDGVNDSP RIHLPLTYSP GSPDIGRHYR SNSPLPSIQL QAQSPSASQK HQVVQDLPAT
NTFVGTGGDD NSTGSDQYSD YSYKTGQPKY NNKQHPHRRV TFSTTNPVQD LQDASQHSYY
DSGLEESETP SSKSSSGPRI GPLTLPEDHY ERTTPDGSIG ETEHPENDIR SLPDVAMTGN
CTTECSELGH SDACWMPGHP SPVRKTRNPP KLSTFVPYQD RGSLGRLANG NARLGGEEHR
PRLPPSRSAY SSSGHDANQD CPLEEVPLSV ASEFPPTSPS AHTPKREIYL
//
